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BMP7 elisa kit :: Human bone morphogenetic protein 7 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS703989
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $375 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,295 +2 FREE 8GB USB
10x96-Strip-Wells  /  $4,330 +5 FREE 8GB USB
 
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 Product Name   

bone morphogenetic protein 7 (BMP7), ELISA Kit

★Popular Item★
 Also Known As   

Human Bone morphogenetic protein 7, BMP-7 ELISA Kit

 Product Synonym Names    Human Bone morphogenetic protein 7; BMP-7 ELISA Kit; OP-1; osteogenic protein 1; bone morphogenetic protein 7
 Product Gene Name   

BMP7 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS703989 Testing Data    Testing Data PDF
 OMIM    112267
 3D Structure    ModBase 3D Structure for P18075
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human BMP7. No significant cross-reactivity or interference between Human BMP7 and analogues was observed.
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 Detection Range    15.6 pg/ml -1000 pg/ml. T
 Sensitivity    3.9 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Developmental Protein
 Protein Biological Process 3    Chondrogenesis
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BMP7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BMP7 purchase    MBS703989 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the bone morphogenetic protein 7 (BMP7) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6 pg/ml -1000 pg/ml. T in biological research samples containing BMP7, with an estimated sensitivity of 3.9 pg/ml. The ELISA analytical biochemical technique of the MBS703989 kit is based on BMP7 antibody-BMP7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BMP7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BMP7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for BMP7 elisa kit

   Introduction: Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene. The protein encoded by this gene is a member of the TGF-beta superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.[2] BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes.[3] It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.[2] BMP7 has been discovered to be crucial in the determination of ventral-dorsal organization in zebrafish. BMP7 causes the expression of ventral phenotypes while its complete inhibition creates a dorsal phenotype. Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism.[4] In many early developmental experiments using zebrafish, scientists used caBMPR (constitutively active) and tBMP (truncated receptor) to determine the effect of BMP7 in embryogensis. They found that the constitutively active, which causes BMP to be expressed everywhere creates a ventralized phenotype, whereas truncated, dorsalized.FOR

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to BMP-7. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for BMP-7 and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB (3,3'5, 5' tetramethyl-benzidine) substrate solution is added to each well. Only those wells that contain BMP-7, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of BMP-7 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of BMP7 elisa kit    BMP7 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS703989. Click to request current manual
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NCBI/Uniprot data below describe general gene information for BMP7. It may not necessarily be applicable to this product.
 NCBI GI #    4502427
 NCBI GeneID    655
 NCBI Accession #    NP_001710.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001719.2 [Other Products]
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 UniProt Primary Accession #    P18075 [Other Products]
 UniProt Secondary Accession #    Q9H512; Q9NTQ7 [Other Products]
 UniProt Related Accession #    P18075 [Other Products]
 Molecular Weight    49,313 Da
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 NCBI Official Full Name    bone morphogenetic protein 7
 NCBI Official Synonym Full Names    bone morphogenetic protein 7
 NCBI Official Symbol    BMP7 [Similar Products]
 NCBI Official Synonym Symbols   
OP-1
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 7; osteogenic protein 1
 UniProt Protein Name    Bone morphogenetic protein 7
 UniProt Synonym Protein Names   
Osteogenic protein 1; OP-1; INN: Eptotermin alfa
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP7 [Similar Products]
 UniProt Synonym Gene Names    OP1; BMP-7; OP-1 [Similar Products]
 UniProt Entry Name    BMP7_HUMAN
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 NCBI Summary for BMP7    The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP7    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
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 Research Articles on BMP7    1. BMP5 and BMP7, involved in cardiomyocyte differentiation defect
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP7 elisa kitPathways associated with BMP7 elisa kit
 Reference Product  PubMed Publications
 BMPR2 elisa kit  >118 publications with BMP7 and BMPR2
 BMPR1A elisa kit  >75 publications with BMP7 and BMPR1A
 SMAD5 elisa kit  >43 publications with BMP7 and SMAD5
 BMPR1B elisa kit  >24 publications with BMP7 and BMPR1B
 ACVR1 elisa kit  >24 publications with BMP7 and ACVR1
 ACVR2A elisa kit  >6 publications with BMP7 and ACVR2A
 SOSTDC1 elisa kit  >4 publications with BMP7 and SOSTDC1
 NOG elisa kit  >4 publications with BMP7 and NOG
 FST elisa kit  >3 publications with BMP7 and FST
 CHRD elisa kit  >2 publications with BMP7 and CHRD
 Products by Pathway  Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
Diseases associated with BMP7 elisa kitOrgans/Tissues associated with BMP7 elisa kit
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >98 publications with BMP7 and Disease Models, Animal
 Fibrosis Antibodies  >95 publications with BMP7 and Fibrosis
 Kidney Diseases Antibodies  >94 publications with BMP7 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >49 publications with BMP7 and Cardiovascular Diseases
 Inflammation Antibodies  >46 publications with BMP7 and Inflammation
 Bone Resorption Antibodies  >35 publications with BMP7 and Bone Resorption
 Necrosis Antibodies  >34 publications with BMP7 and Necrosis
 Renal Insufficiency Antibodies  >32 publications with BMP7 and Renal Insufficiency
 Hypertension Antibodies  >30 publications with BMP7 and Hypertension
 Neoplasm Metastasis Antibodies  >26 publications with BMP7 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1131 publications with BMP7 and Bone
 Kidney Antibodies  >167 publications with BMP7 and Kidney
 Embryonic Tissue Antibodies  >148 publications with BMP7 and Embryonic Tissue
 Connective Tissue Antibodies  >125 publications with BMP7 and Connective Tissue
 Brain Antibodies  >92 publications with BMP7 and Brain
 Muscle Antibodies  >82 publications with BMP7 and Muscle
 Mouth Antibodies  >77 publications with BMP7 and Mouth
 Eye Antibodies  >63 publications with BMP7 and Eye
 Prostate Antibodies  >34 publications with BMP7 and Prostate
 Heart Antibodies  >27 publications with BMP7 and Heart
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