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BUB1B elisa kit :: Human budding uninhibited by benzimidazoles 1 homolog beta (yeast) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9329895 BUB1B elisa kit
Unit / Price
48-Strip-Wells  /  $500 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,250 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,395 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

budding uninhibited by benzimidazoles 1 homolog beta (yeast) (BUB1B), ELISA Kit

★Popular Item★
 Also Known As   

Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, BUB1B ELISA Kit

 Product Synonym Names    Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) ELISA kit; BUB1beta; BUBR1; Bub1A; MAD3L; SSK1; hBUBR1; BUB1 budding uninhibited by benzimidazoles 1 homolog beta; MAD3/BUB1-related protein kinase; budding uninhibited by benzimidazoles 1 beta; budding uninhibit; budding uninhibited by benzimidazoles 1 homolog beta (yeast)
 Product Gene Name   

BUB1B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    602860
 3D Structure    ModBase 3D Structure for O60566
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
 Assay Type    Sandwich
 Detection Range    0.625 ng/ml - 20 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BUB1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BUB1B purchase    MBS9329895 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the budding uninhibited by benzimidazoles 1 homolog beta (yeast) (BUB1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing BUB1B, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9329895 kit is based on BUB1B antibody-BUB1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BUB1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BUB1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for BUB1B elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of BUB1B (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9329895. Click to request current manual
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NCBI/Uniprot data below describe general gene information for BUB1B. It may not necessarily be applicable to this product.
 NCBI GI #    59814247
 NCBI GeneID    701
 NCBI Accession #    NP_001202.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_001211.5 [Other Products]
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 UniProt Primary Accession #    O60566 [Other Products]
 UniProt Secondary Accession #    O60501; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4; B2R6U0; B4DL09; B4DLG3 [Other Products]
 UniProt Related Accession #    O60566 [Other Products]
 Molecular Weight    119,545 Da
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 NCBI Official Full Name    mitotic checkpoint serine/threonine-protein kinase BUB1 beta
 NCBI Official Synonym Full Names    BUB1 mitotic checkpoint serine/threonine kinase B
 NCBI Official Symbol    BUB1B [Similar Products]
 NCBI Official Synonym Symbols   
MVA1; SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta
[Similar Products]
 NCBI Protein Information    mitotic checkpoint serine/threonine-protein kinase BUB1 beta; mitotic checkpoint kinase MAD3L; MAD3/BUB1-related protein kinase; budding uninhibited by benzimidazoles 1 homolog beta
 UniProt Protein Name    Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
 UniProt Synonym Protein Names   
MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1
 Protein Family    Mitotic checkpoint serine/threonine-protein kinase
 UniProt Gene Name    BUB1B [Similar Products]
 UniProt Synonym Gene Names    BUBR1; MAD3L; SSK1; hBUBR1 [Similar Products]
 UniProt Entry Name    BUB1B_HUMAN
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 NCBI Summary for BUB1B    This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BUB1B    BUB1B: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3. Part of a complex containing BUB3, CDC20 and BUB1B. Interacts with anaphase-promoting complex/cyclosome (APC/C). Interacts with CASC5. Induced during mitosis. Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. Kinase activity stimulated by CENPE. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; EC 2.7.11.1; Kinase, protein; Other group; BUB family

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: kinetochore; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; outer kinetochore of condensed chromosome; spindle midzone; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity

Biological Process: cell proliferation; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; apoptosis; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; protein amino acid phosphorylation; mitotic metaphase/anaphase transition

Disease: Mosaic Variegated Aneuploidy Syndrome 1; Premature Chromatid Separation Trait
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 Research Articles on BUB1B    1. the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BUB1B elisa kitPathways associated with BUB1B elisa kit
 Reference Product  PubMed Publications
 BUB3 elisa kit  >6 publications with BUB1B and BUB3
 CDC20 elisa kit  >6 publications with BUB1B and CDC20
 CENPE elisa kit  >3 publications with BUB1B and CENPE
 BRCA2 elisa kit  >2 publications with BUB1B and BRCA2
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with BUB1B elisa kitOrgans/Tissues associated with BUB1B elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >29 publications with BUB1B and Neoplasms
 Carcinoma Antibodies  >8 publications with BUB1B and Carcinoma
 Colorectal Neoplasms Antibodies  >8 publications with BUB1B and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >7 publications with BUB1B and Breast Neoplasms
 Skin Diseases Antibodies  >7 publications with BUB1B and Skin Diseases
 Adenocarcinoma Antibodies  >5 publications with BUB1B and Adenocarcinoma
 Microcephaly Antibodies  >5 publications with BUB1B and Microcephaly
 Colonic Neoplasms Antibodies  >3 publications with BUB1B and Colonic Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with BUB1B and Neoplasms, Experimental
 Rhabdomyosarcoma, Embryonal Antibodies  >2 publications with BUB1B and Rhabdomyosarcoma, Embryonal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with BUB1B and Blood
 Intestine Antibodies  >2 publications with BUB1B and Intestine
 Bone Antibodies  >2 publications with BUB1B and Bone
 Skin Antibodies  >1 publications with BUB1B and Skin
 Thymus Antibodies  >1 publications with BUB1B and Thymus
 Ovary Antibodies  >1 publications with BUB1B and Ovary
 Prostate Antibodies  >1 publications with BUB1B and Prostate
 Stomach Antibodies  >1 publications with BUB1B and Stomach
 Mouth Antibodies  >1 publications with BUB1B and Mouth
 Embryonic Tissue Antibodies  >1 publications with BUB1B and Embryonic Tissue
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