NP_000712.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
261,731 Da
NCBI Official Full Name
voltage-dependent R-type calcium channel subunit alpha-1E isoform 3
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, R type, alpha 1E subunit
NCBI Protein Information
voltage-dependent R-type calcium channel subunit alpha-1E; brain calcium channel II; voltage-gated calcium channel alpha 1E subunit; voltage-dependent calcium channel alpha 1E subunit; voltage-gated calcium channel alpha subunit Cav2.3; voltage-gated calcium channel subunit alpha Cav2.3; calcium channel, voltage-dependent, alpha 1E subunit; calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, R type, alpha-1 polypeptide, isoform 6
UniProt Protein Name
Voltage-dependent R-type calcium channel subunit alpha-1E
UniProt Synonym Protein Names
Brain calcium channel II; BII; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3
UniProt Synonym Gene Names
UniProt Entry Name
CAC1E_HUMAN
NCBI Summary for CACNA1E
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
UniProt Comments for CACNA1E
CACNA1E: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component: plasma membrane; voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity; high voltage-gated calcium channel activity; calcium ion binding
Biological Process: membrane depolarization; synaptic transmission; transport; energy reserve metabolic process; regulation of insulin secretion
Research Articles on CACNA1E
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Products associated with CACNA1E elisa kit
Pathways associated with CACNA1E elisa kit
Diseases associated with CACNA1E elisa kit
Organs/Tissues associated with CACNA1E elisa kit
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