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CACNB4 elisa kit :: Human calcium channel, voltage-dependent, beta 4 subunit ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9336279 CACNB4 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

calcium channel, voltage-dependent, beta 4 subunit (CACNB4), ELISA Kit

 Also Known As   

Human Voltage-dependent L-type calcium channel subunit beta-4, CACNB4 ELISA Kit

 Product Synonym Names    Human Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) ELISA kit; CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6; OTTHUMP00000207247; OTTHUMP00000207249; dihydropyridine-sensitive L-type; calcium channel beta-4 subunit; calcium channel; voltage-dependent; beta 4 subunit
 Product Gene Name   

CACNB4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    613855
 3D Structure    ModBase 3D Structure for O00305
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CACNB4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CACNB4 purchase    MBS9336279 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the calcium channel, voltage-dependent, beta 4 subunit (CACNB4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CACNB4. The ELISA analytical biochemical technique of the MBS9336279 kit is based on CACNB4 antibody-CACNB4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CACNB4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CACNB4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CACNB4. It may not necessarily be applicable to this product.
 NCBI GI #    54607064
 NCBI GeneID    785
 NCBI Accession #    NP_000717.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000726.3 [Other Products]
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 UniProt Primary Accession #    O00305 [Other Products]
 UniProt Secondary Accession #    O60515; Q6B000; Q96L40; A7BJ74; A8K1Y4; B4DG40 [Other Products]
 UniProt Related Accession #    O00305 [Other Products]
 Molecular Weight    58,169 Da
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 NCBI Official Full Name    voltage-dependent L-type calcium channel subunit beta-4 isoform b
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, beta 4 subunit
 NCBI Official Symbol    CACNB4 [Similar Products]
 NCBI Official Synonym Symbols   
EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4
[Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit beta-4; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit beta-4
 UniProt Synonym Protein Names   
Calcium channel voltage-dependent subunit beta 4
 Protein Family    Voltage-dependent L-type calcium channel
 UniProt Gene Name    CACNB4 [Similar Products]
 UniProt Synonym Gene Names    CACNLB4; CAB4 [Similar Products]
 UniProt Entry Name    CACB4_HUMAN
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 NCBI Summary for CACNB4    This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for CACNB4    CACNB4: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are the cause of susceptibility to epilepsy, idiopathic generalized type 9 (EIG9). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6). EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Defects in CACNB4 are the cause of episodic ataxia type 5 (EA5). EA5 is a disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia. Belongs to the calcium channel beta subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: internal side of plasma membrane; plasma membrane; voltage-gated calcium channel complex; synapse; cytosol

Molecular Function: voltage-gated calcium channel activity; protein binding; high voltage-gated calcium channel activity; protein kinase binding

Biological Process: Peyer's patch development; spleen development; axon guidance; synaptic transmission, glutamatergic; thymus development; gamma-aminobutyric acid secretion; adult walking behavior; T cell receptor signaling pathway; cellular calcium ion homeostasis; synaptic transmission; membrane depolarization; cAMP metabolic process; transport; action potential propagation; detection of light stimulus involved in visual perception; muscle fiber development; gamma-aminobutyric acid signaling pathway; neuromuscular junction development

Disease: Episodic Ataxia, Type 5; Epilepsy, Idiopathic Generalized, Susceptibility To, 9
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 Research Articles on CACNB4    1. Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CACNB4 elisa kitPathways associated with CACNB4 elisa kit
 Reference Product  PubMed Publications
 CACNA1A elisa kit  >11 publications with CACNB4 and CACNA1A
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Diseases associated with CACNB4 elisa kitOrgans/Tissues associated with CACNB4 elisa kit
 Disease Name  Pubmed Publications
 Ataxia Antibodies  >12 publications with CACNB4 and Ataxia
 Epilepsy, Generalized Antibodies  >9 publications with CACNB4 and Epilepsy, Generalized
 Disease Models, Animal Antibodies  >6 publications with CACNB4 and Disease Models, Animal
 Cerebellar Diseases Antibodies  >5 publications with CACNB4 and Cerebellar Diseases
 Myoclonic Epilepsy, Juvenile Antibodies  >4 publications with CACNB4 and Myoclonic Epilepsy, Juvenile
 Dizziness Antibodies  >3 publications with CACNB4 and Dizziness
 Migraine Disorders Antibodies  >3 publications with CACNB4 and Migraine Disorders
 Pain Antibodies  >2 publications with CACNB4 and Pain
 Brain Ischemia Antibodies  >1 publications with CACNB4 and Brain Ischemia
 Cerebral Infarction Antibodies  >1 publications with CACNB4 and Cerebral Infarction
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with CACNB4 and Brain
 Muscle Antibodies  >4 publications with CACNB4 and Muscle
 Kidney Antibodies  >2 publications with CACNB4 and Kidney
 Testis Antibodies  >1 publications with CACNB4 and Testis
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