NP_000087.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
122,205 Da
NCBI Official Full Name
ceruloplasmin
NCBI Official Synonym Full Names
ceruloplasmin (ferroxidase)
NCBI Official Synonym Symbols
NCBI Protein Information
ceruloplasmin
UniProt Protein Name
Ceruloplasmin
UniProt Synonym Protein Names
Ferroxidase
UniProt Entry Name
CERU_HUMAN
NCBI Summary for CP
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for CP
Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense
Catalytic activity: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Cofactor: Binds 6 copper ions per monomer.
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Products associated with CP elisa kit
Pathways associated with CP elisa kit
Diseases associated with CP elisa kit
Organs/Tissues associated with CP elisa kit
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