NP_612145.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,466 Da
NCBI Official Full Name
serine palmitoyltransferase small subunit A
NCBI Official Synonym Full Names
serine palmitoyltransferase, small subunit A
NCBI Protein Information
serine palmitoyltransferase small subunit A; small subunit of serine palmitoyltransferase A
UniProt Protein Name
Serine palmitoyltransferase small subunit A
UniProt Synonym Protein Names
Small subunit of serine palmitoyltransferase A; ssSPTa
UniProt Synonym Gene Names
UniProt Entry Name
SPTSA_HUMAN
NCBI Summary for C14orf147
Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
UniProt Comments for C14orf147
SPTSSA: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA. Belongs to the SPTSS family. SPTSSA subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q13.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: serine C-palmitoyltransferase activity; protein binding
Biological Process: sphingolipid biosynthetic process
Research Articles on C14orf147
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Pathways associated with C14orf147 elisa kit
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