NP_001034624.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,484 Da
NCBI Official Full Name
spindle and kinetochore-associated protein 1
NCBI Official Synonym Full Names
spindle and kinetochore associated complex subunit 1
NCBI Official Synonym Symbols
NCBI Protein Information
spindle and kinetochore-associated protein 1; spindle and KT (kinetochore) associated 1
UniProt Protein Name
Spindle and kinetochore-associated protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SKA1_HUMAN
UniProt Comments for C18orf24
SKA1: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. Belongs to the SKA1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: microtubule cytoskeleton; spindle microtubule; outer kinetochore of condensed chromosome; cytosol
Molecular Function: protein binding; microtubule binding
Biological Process: mitosis; cell division; mitotic cell cycle; regulation of microtubule polymerization or depolymerization; chromosome segregation
Research Articles on C18orf24
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Products associated with C18orf24 elisa kit
Pathways associated with C18orf24 elisa kit
Diseases associated with C18orf24 elisa kit
Organs/Tissues associated with C18orf24 elisa kit
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