NP_001164266.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,747 Da
NCBI Official Full Name
all-trans retinoic acid-induced differentiation factor isoform c
NCBI Official Synonym Full Names
all-trans retinoic acid-induced differentiation factor
NCBI Official Synonym Symbols
p18; APR3; APR-3; APR--3; PRO240; C2orf28; HSPC013 [Similar Products]
NCBI Protein Information
all-trans retinoic acid-induced differentiation factor; apoptosis related protein 3; apoptosis-related protein 3; apoptosis related protein APR-3
UniProt Protein Name
All-trans retinoic acid-induced differentiation factor
UniProt Synonym Protein Names
Apoptosis-related protein 3; APR-3; p18
UniProt Synonym Gene Names
UniProt Entry Name
ARAID_HUMAN
NCBI Summary for C2orf28
This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]
UniProt Comments for C2orf28
APR3: May play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines. Weakly expressed in hematopoietic cell lines. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: perinuclear region of cytoplasm; plasma membrane; integral to membrane; nuclear envelope
Molecular Function: protein binding
Biological Process: positive regulation of osteoblast differentiation; regulation of gene expression; negative regulation of osteoblast proliferation; positive regulation of bone mineralization; cell differentiation
Research Articles on C2orf28
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