NP_064515.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
12,337 Da
NCBI Official Full Name
uncharacterized protein C8orf4
NCBI Official Synonym Full Names
chromosome 8 open reading frame 4
NCBI Official Synonym Symbols
NCBI Protein Information
uncharacterized protein C8orf4; human thyroid cancer 1; thyroid cancer protein 1
UniProt Protein Name
Uncharacterized protein C8orf4
UniProt Synonym Protein Names
Thyroid cancer protein 1; TC-1
UniProt Synonym Gene Names
UniProt Entry Name
CH004_HUMAN
NCBI Summary for C8orf4
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
UniProt Comments for C8orf4
C8orf4: May decrease apoptosis.
Chromosomal Location of Human Ortholog: 8p11.2
Biological Process: apoptosis
Research Articles on C8orf4
Precautions
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Disclaimer
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Diseases associated with C8orf4 elisa kit
Organs/Tissues associated with C8orf4 elisa kit
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