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FXII elisa kit :: Human coagulation factor XII, FXII ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9301618 FXII elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

coagulation factor XII, FXII, ELISA Kit

★Popular Item★
 Also Known As   

Human coagulation factor XII, FXII ELISA Kit

 Product Gene Name   

FXII elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 5; NC_000005.9 (176829139..176836577, complement). Location: 5q33-qter
 OMIM    234000
 3D Structure    ModBase 3D Structure for P00748
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    0.25 ug/ml - 8 ug/ml
 Sensitivity    0.1 ug/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FXII elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FXII purchase    MBS9301618 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the coagulation factor XII, FXII, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ug/ml - 8 ug/ml in biological research samples containing FXII, with an estimated sensitivity of 0.1 ug/ml. The ELISA analytical biochemical technique of the MBS9301618 kit is based on FXII antibody-FXII antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FXII antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FXII. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FXII elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of F12 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9301618. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FXII. It may not necessarily be applicable to this product.
 NCBI GI #    903736
 NCBI GeneID    2161
 NCBI Accession #    AAB59491.1 [Other Products]
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 UniProt Primary Accession #    P00748 [Other Products]
 UniProt Secondary Accession #    P78339 [Other Products]
 UniProt Related Accession #    P00748 [Other Products]
 Molecular Weight    67,792 Da
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 NCBI Official Full Name    coagulation factor XII
 NCBI Official Synonym Full Names    coagulation factor XII (Hageman factor)
 NCBI Official Symbol    F12 [Similar Products]
 NCBI Official Synonym Symbols   
HAF; HAE3; HAEX
[Similar Products]
 NCBI Protein Information    coagulation factor XII; Hageman factor; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain
 UniProt Protein Name    Coagulation factor XII
 UniProt Synonym Protein Names   
Hageman factor
 UniProt Gene Name    F12 [Similar Products]
 UniProt Synonym Gene Names    HAF [Similar Products]
 UniProt Entry Name    FA12_HUMAN
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 NCBI Summary for FXII    This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FXII    F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family.

Protein type: Chaperone; Protease; Secreted, signal peptide; Secreted; EC 3.4.21.38

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: extracellular space; plasma membrane; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; misfolded protein binding

Biological Process: response to misfolded protein; positive regulation of blood coagulation; proteolysis; protein autoprocessing; fibrinolysis; plasma kallikrein-kinin cascade; innate immune response; positive regulation of fibrinolysis; zymogen activation; protein processing; blood coagulation; blood coagulation, intrinsic pathway; Factor XII activation

Disease: Angioedema, Hereditary, Type Iii; Factor Xii Deficiency
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 Research Articles on FXII    1. Immobilized Ni(2+) and Cu(2+) bind FXII, FXI and high molecular weight kininogen with high affinity and stimulate activation of the contact pathway, driving FXII-mediated coagulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FXII elisa kitPathways associated with FXII elisa kit
 Reference Product  PubMed Publications
 GP1BA elisa kit  >5 publications with FXII and GP1BA
 SERPING1 elisa kit  >3 publications with FXII and SERPING1
 KNG1 elisa kit  >3 publications with FXII and KNG1
 KLKB1 elisa kit  >2 publications with FXII and KLKB1
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
Diseases associated with FXII elisa kitOrgans/Tissues associated with FXII elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >150 publications with FXII and Neoplasms
 Cardiovascular Diseases Antibodies  >50 publications with FXII and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >46 publications with FXII and Nervous System Diseases
 Adenocarcinoma Antibodies  >25 publications with FXII and Adenocarcinoma
 Necrosis Antibodies  >24 publications with FXII and Necrosis
 Cell Transformation, Neoplastic Antibodies  >20 publications with FXII and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >18 publications with FXII and Liver Neoplasms
 Liver Diseases Antibodies  >18 publications with FXII and Liver Diseases
 Fetal Death Antibodies  >16 publications with FXII and Fetal Death
 Fetal Diseases Antibodies  >16 publications with FXII and Fetal Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >96 publications with FXII and Brain
 Embryonic Tissue Antibodies  >80 publications with FXII and Embryonic Tissue
 Kidney Antibodies  >64 publications with FXII and Kidney
 Liver Antibodies  >62 publications with FXII and Liver
 Connective Tissue Antibodies  >47 publications with FXII and Connective Tissue
 Testis Antibodies  >41 publications with FXII and Testis
 Lung Antibodies  >40 publications with FXII and Lung
 Intestine Antibodies  >20 publications with FXII and Intestine
 Uterus Antibodies  >17 publications with FXII and Uterus
 Stomach Antibodies  >12 publications with FXII and Stomach
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