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C4BPA elisa kit :: Human complement component 4 binding protein, alpha ELISA Kit

Scan QR to view Datasheet Catalog #    MBS700333
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
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 Product Name   

complement component 4 binding protein, alpha (C4BPA), ELISA Kit

★Popular Item★
 Also Known As   

Human C4 binding protein, C4BP ELISA Kit

 Product Synonym Names    Human C4 binding protein; C4BP ELISA Kit; RP11-164O23.4; C4BP; PRP; C4b binding protein; alpha chain; complement component 4 binding protein; alpha chain; complement component 4-binding protein; alpha; proline-rich protein; complement component 4 binding protein; alpha
 Product Gene Name   

C4BPA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS700333 Testing Data    Testing Data PDF
 OMIM    120830
 3D Structure    ModBase 3D Structure for P04003
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human C4BPA. No significant cross-reactivity or interference between Human C4BPA and analogues was observed.
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 Samples    Serum, plasma and tissue homogenates
 Detection Range    0.625 ng/ml-40 ng/ml
 Sensitivity    0.156 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Complement
 Protein Biological Process 3    Complement pathway
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of C4BPA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for C4BPA purchase    MBS700333 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the complement component 4 binding protein, alpha (C4BPA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml-40 ng/ml in biological research samples containing C4BPA, with an estimated sensitivity of 0.156 ng/ml. The ELISA analytical biochemical technique of the MBS700333 kit is based on C4BPA antibody-C4BPA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C4BPA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C4BPA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for C4BPA elisa kit

   Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to C4BP. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for C4BP and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB (3,3',5,5' tetramethyl-benzidine) substrate solution is added to each well. Only those wells that contain C4BP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of C4BP in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of C4BPA elisa kit    C4BPA elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS700333. Click to request current manual
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NCBI/Uniprot data below describe general gene information for C4BPA. It may not necessarily be applicable to this product.
 NCBI GI #    4502503
 NCBI GeneID    722
 NCBI Accession #    NP_000706.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000715.3 [Other Products]
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 UniProt Primary Accession #    P04003 [Other Products]
 UniProt Secondary Accession #    Q5VVQ8 [Other Products]
 UniProt Related Accession #    P04003 [Other Products]
 Molecular Weight    67,033 Da
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 NCBI Official Full Name    C4b-binding protein alpha chain
 NCBI Official Synonym Full Names    complement component 4 binding protein, alpha
 NCBI Official Symbol    C4BPA [Similar Products]
 NCBI Official Synonym Symbols   
PRP; C4BP
[Similar Products]
 NCBI Protein Information    C4b-binding protein alpha chain; proline-rich protein
 UniProt Protein Name    C4b-binding protein alpha chain
 UniProt Synonym Protein Names   
Proline-rich protein; PRP
 Protein Family    C4b-binding protein
 UniProt Gene Name    C4BPA [Similar Products]
 UniProt Synonym Gene Names    C4BP; C4bp; PRP [Similar Products]
 UniProt Entry Name    C4BPA_HUMAN
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 NCBI Summary for C4BPA    This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C4BPA    Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
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 Research Articles on C4BPA    1. these data suggest that when C4BP is bound to Ail, fI can cleave and inactivate C4b that has bound covalently to bacterial surface structures as well as C4b bound noncovalently to Ail.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C4BPA elisa kitPathways associated with C4BPA elisa kit
 Reference Product  PubMed Publications
 C4B elisa kit  >77 publications with C4BPA and C4B
 C4BPB elisa kit  >21 publications with C4BPA and C4BPB
 PROS1 elisa kit  >2 publications with C4BPA and PROS1
 APCS elisa kit  >2 publications with C4BPA and APCS
 CFI elisa kit  >2 publications with C4BPA and CFI
 CD40 elisa kit  >1 publications with C4BPA and CD40
 Products by Pathway  Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
Diseases associated with C4BPA elisa kitOrgans/Tissues associated with C4BPA elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with C4BPA and Inflammation
 Cardiovascular Diseases Antibodies  >5 publications with C4BPA and Cardiovascular Diseases
 Autoimmune Diseases Antibodies  >5 publications with C4BPA and Autoimmune Diseases
 Blood Coagulation Disorders Antibodies  >4 publications with C4BPA and Blood Coagulation Disorders
 Carcinoma, Hepatocellular Antibodies  >4 publications with C4BPA and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >4 publications with C4BPA and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with C4BPA and Liver Neoplasms
 Necrosis Antibodies  >3 publications with C4BPA and Necrosis
 Lung Diseases Antibodies  >3 publications with C4BPA and Lung Diseases
 Lung Neoplasms Antibodies  >2 publications with C4BPA and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with C4BPA and Blood
 Liver Antibodies  >4 publications with C4BPA and Liver
 Uterus Antibodies  >3 publications with C4BPA and Uterus
 Muscle Antibodies  >2 publications with C4BPA and Muscle
 Connective Tissue Antibodies  >1 publications with C4BPA and Connective Tissue
 Mammary Gland Antibodies  >1 publications with C4BPA and Mammary Gland
 Brain Antibodies  >1 publications with C4BPA and Brain
 Lung Antibodies  >1 publications with C4BPA and Lung
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