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C6 elisa kit :: Human complement component 6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS934887
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

complement component 6 (C6), ELISA Kit

 Also Known As   

Human Complement component C6, C6 ELISA Kit

 Product Synonym Names    Human Complement component C6 (C6) ELISA kit; complement component 6
 Product Gene Name   

C6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS934887 Testing Data    Testing Data PDF
 OMIM    gene 612446
 3D Structure    ModBase 3D Structure for P13671
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human C6. No significant cross-reactivity or interference between human C6 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Sandwich
 Detection Range    62.5 pg/ml -4000 pg/ml.
 Sensitivity    The minimum detectable dose of human C6 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of C6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for C6 purchase    MBS934887 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the complement component 6 (C6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5 pg/ml -4000 pg/ml in biological research samples containing C6, with an estimated sensitivity of The minimum detectable dose of human C6 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS934887 kit is based on C6 antibody-C6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for C6 elisa kit

   Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for C6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any C6 present is bound by the immobilized antibody. After removing any unbound substances, a Horseradish Peroxidase (HRP)-conjugated antibody specific for C6 is added to the wells. Following a wash to remove any unbound reagent, a substrate solution is added to the wells and color develops in proportion to the amount of C6 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of C6 elisa kit    C6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS934887. Click to request current manual
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NCBI/Uniprot data below describe general gene information for C6. It may not necessarily be applicable to this product.
 NCBI GI #    169636415
 NCBI GeneID    729
 NCBI Accession #    NP_000056.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000065.3 [Other Products]
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 UniProt Primary Accession #    P13671 [Other Products]
 UniProt Related Accession #    P13671 [Other Products]
 Molecular Weight    104,786 Da
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 NCBI Official Full Name    complement component C6
 NCBI Official Synonym Full Names    complement component 6
 NCBI Official Symbol    C6 [Similar Products]
 NCBI Protein Information    complement component C6
 UniProt Protein Name    Complement component C6
 Protein Family    Complement component
 UniProt Gene Name    C6 [Similar Products]
 UniProt Entry Name    CO6_HUMAN
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 NCBI Summary for C6    This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
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 UniProt Comments for C6    C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Molecular Function: protein binding

Biological Process: positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; in utero embryonic development; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 6 Deficiency
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 Research Articles on C6    1. Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with C6 elisa kitDiseases associated with C6 elisa kit
 Products by Pathway  Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3760 publications with C6 and Neoplasms
 Nervous System Diseases Antibodies  >2774 publications with C6 and Nervous System Diseases
 Brain Diseases Antibodies  >1342 publications with C6 and Brain Diseases
 Pain Antibodies  >668 publications with C6 and Pain
 Disease Models, Animal Antibodies  >460 publications with C6 and Disease Models, Animal
 Drug Toxicity Antibodies  >457 publications with C6 and Drug Toxicity
 Necrosis Antibodies  >359 publications with C6 and Necrosis
 COMPLEMENT COMPONENT 6 DEFICIENCY Antibodies  >297 publications with C6 and COMPLEMENT COMPONENT 6 DEFICIENCY
 Postoperative Complications Antibodies  >254 publications with C6 and Postoperative Complications
 Inflammation Antibodies  >243 publications with C6 and Inflammation
Organs/Tissues associated with C6 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2492 publications with C6 and Brain
 Liver Antibodies  >461 publications with C6 and Liver
 Kidney Antibodies  >361 publications with C6 and Kidney
 Heart Antibodies  >282 publications with C6 and Heart
 Lung Antibodies  >225 publications with C6 and Lung
 Connective Tissue Antibodies  >85 publications with C6 and Connective Tissue
 Bladder Antibodies  >68 publications with C6 and Bladder
 Ovary Antibodies  >58 publications with C6 and Ovary
 Trachea Antibodies  >36 publications with C6 and Trachea
 Testis Antibodies  >35 publications with C6 and Testis
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