NP_001877.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,374 Da
NCBI Official Full Name
beta-crystallin A4
NCBI Official Synonym Full Names
crystallin, beta A4
NCBI Protein Information
beta-crystallin A4; beta-A4 crystallin; eye lens structural protein; crystallin, beta polypeptide A4
UniProt Protein Name
Beta-crystallin A4
UniProt Synonym Protein Names
Beta-A4 crystallin
UniProt Entry Name
CRBA4_HUMAN
NCBI Summary for CRYBA4
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
UniProt Comments for CRYBA4
CRYBA4: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family.
Chromosomal Location of Human Ortholog: 22q12.1
Molecular Function: structural constituent of eye lens
Biological Process: camera-type eye development; visual perception
Disease: Cataract 23
Research Articles on CRYBA4
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Diseases associated with CRYBA4 elisa kit
Organs/Tissues associated with CRYBA4 elisa kit
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