NP_060119.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,623 Da
NCBI Official Full Name
metal transporter CNNM2 isoform 1
NCBI Official Synonym Full Names
cyclin and CBS domain divalent metal cation transport mediator 2
NCBI Official Synonym Symbols
NCBI Protein Information
metal transporter CNNM2; cyclin M2; ancient conserved domain-containing protein 2
UniProt Protein Name
Metal transporter CNNM2
UniProt Synonym Protein Names
Ancient conserved domain-containing protein 2; Cyclin-M2
UniProt Synonym Gene Names
UniProt Entry Name
CNNM2_HUMAN
NCBI Summary for CNNM2
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for CNNM2
CNNM2: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+). Defects in CNNM2 are the cause of hypomagnesemia type 6 (HOMG6). A renal disease characterized by severely lowered serum magnesium levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly variable and some affected individuals are asymptomatic. Belongs to the ACDP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: basolateral plasma membrane; integral to membrane
Biological Process: magnesium ion transport
Disease: Hypomagnesemia, Seizures, And Mental Retardation; Hypomagnesemia 6, Renal
Research Articles on CNNM2
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Diseases associated with CNNM2 elisa kit
Organs/Tissues associated with CNNM2 elisa kit
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