NP_004927.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,078 Da
NCBI Official Full Name
cyclin-dependent kinase 4 inhibitor B isoform 1
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
NCBI Official Synonym Symbols
P15; MTS2; TP15; CDK4I; INK4B; p15INK4b [Similar Products]
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor B; MTS-2; p14-INK4b; p14_INK4B; p15-INK4b; p15_INK4B; CDK4B inhibitor; p14_CDK inhibitor; p15 CDK inhibitor; CDK inhibitory protein; multiple tumor suppressor 2; cyclin-dependent kinases 4 and 6 binding protein
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor B
UniProt Synonym Protein Names
Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B
UniProt Synonym Gene Names
UniProt Entry Name
CDN2B_HUMAN
NCBI Summary for CDKN2B
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for CDKN2B
p15-INK4B: a potent inhibitor that nteracts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest.
Protein type: Tumor suppressor; Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
Biological Process: spleen development; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; megakaryocyte differentiation; mitotic cell cycle checkpoint; positive regulation of transforming growth factor beta receptor signaling pathway; cellular response to nutrient; liver development; response to organic cyclic substance; negative regulation of cell proliferation; transforming growth factor beta receptor signaling pathway; response to cytokine stimulus; cellular response to extracellular stimulus; negative regulation of phosphorylation; positive regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; cell cycle arrest; negative regulation of epithelial cell proliferation; aging
Research Articles on CDKN2B
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Products associated with CDKN2B elisa kit
Pathways associated with CDKN2B elisa kit
Diseases associated with CDKN2B elisa kit
Organs/Tissues associated with CDKN2B elisa kit
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