NP_000091.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
11,140 Da
NCBI Official Full Name
cystatin-B
NCBI Official Synonym Full Names
cystatin B (stefin B)
NCBI Official Synonym Symbols
PME; ULD; CST6; EPM1; STFB; EPM1A [Similar Products]
NCBI Protein Information
cystatin-B; CPI-B; liver thiol proteinase inhibitor
UniProt Protein Name
Cystatin-B
UniProt Synonym Protein Names
CPI-B; Liver thiol proteinase inhibitor; Stefin-B
UniProt Synonym Gene Names
UniProt Entry Name
CYTB_HUMAN
NCBI Summary for CSTB
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008]
UniProt Comments for CSTB
Function: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Research Articles on CSTB
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Products associated with CSTB elisa kit
Diseases associated with CSTB elisa kit
Organs/Tissues associated with CSTB elisa kit
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