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CYP46A1 elisa kit :: Human cytochrome P450, family 46, subfamily A, polypeptide 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9336649 CYP46A1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1), ELISA Kit

 Also Known As   

Human Cholesterol 24-hydroxylase, CYP46A1 ELISA Kit

 Product Synonym Names    Human Cholesterol 24-hydroxylase (CYP46A1) ELISA kit; CP46; CYP46; cholesterol 24-hydroxylase; cytochrome P450; family 46; cytochrome P450; subfamily 46 (cholesterol 24-hydroxylase) ; cytochrome P450; family 46; subfamily A; polypeptide 1
 Product Gene Name   

CYP46A1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    604087
 3D Structure    ModBase 3D Structure for Q9Y6A2
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Assay Type    Quantitative Sandwich
 Detection Range    1.56ng/ml-50ng/ml.
 Sensitivity    0.1ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CYP46A1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CYP46A1 purchase    MBS9336649 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.56ng/ml-50ng/ml in biological research samples containing CYP46A1, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS9336649 kit is based on CYP46A1 antibody-CYP46A1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CYP46A1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CYP46A1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for CYP46A1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CYP46A1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9336649. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CYP46A1. It may not necessarily be applicable to this product.
 NCBI GI #    5729796
 NCBI GeneID    10858
 NCBI Accession #    NP_006659.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006668.1 [Other Products]
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 UniProt Primary Accession #    Q9Y6A2 [Other Products]
 UniProt Secondary Accession #    Q8N2B0; B4DHP8; E7EQG9 [Other Products]
 UniProt Related Accession #    Q9Y6A2 [Other Products]
 Molecular Weight    56,821 Da
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 NCBI Official Full Name    cholesterol 24-hydroxylase
 NCBI Official Synonym Full Names    cytochrome P450, family 46, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP46A1 [Similar Products]
 NCBI Official Synonym Symbols   
CP46; CYP46
[Similar Products]
 NCBI Protein Information    cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
 UniProt Protein Name    Cholesterol 24-hydroxylase
 UniProt Synonym Protein Names   
Cytochrome P450 46A1
 Protein Family    Cholesterol 24-hydroxylase
 UniProt Gene Name    CYP46A1 [Similar Products]
 UniProt Synonym Gene Names    CYP46; CH24H [Similar Products]
 UniProt Entry Name    CP46A_HUMAN
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 NCBI Summary for CYP46A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP46A1    CYP46A1: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis; EC 1.14.13.98; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity

Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
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 Research Articles on CYP46A1    1. results of meta-analysis suggested that CYP46A1 rs754203 is a minor risk factor for Alzheimer's disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CYP46A1 elisa kitDiseases associated with CYP46A1 elisa kit
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Synthesis Of Bile Acids And Bile Salts Pathway antibodies  Synthesis Of Bile Acids And Bile Salts Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >62 publications with CYP46A1 and Brain Diseases
 Nervous System Diseases Antibodies  >58 publications with CYP46A1 and Nervous System Diseases
 Alzheimer Disease Antibodies  >54 publications with CYP46A1 and Alzheimer Disease
 Mental Disorders Antibodies  >52 publications with CYP46A1 and Mental Disorders
 Fatty Liver Antibodies  >5 publications with CYP46A1 and Fatty Liver
 Cognition Disorders Antibodies  >4 publications with CYP46A1 and Cognition Disorders
 Cardiovascular Diseases Antibodies  >4 publications with CYP46A1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with CYP46A1 and Liver Diseases
 Congenital Abnormalities Antibodies  >3 publications with CYP46A1 and Congenital Abnormalities
 Brain Injuries Antibodies  >3 publications with CYP46A1 and Brain Injuries
Organs/Tissues associated with CYP46A1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >96 publications with CYP46A1 and Brain
 Eye Antibodies  >6 publications with CYP46A1 and Eye
 Nerve Antibodies  >4 publications with CYP46A1 and Nerve
 Heart Antibodies  >3 publications with CYP46A1 and Heart
 Embryonic Tissue Antibodies  >1 publications with CYP46A1 and Embryonic Tissue
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