NP_001035965.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,201 Da
NCBI Official Full Name
neutrophil defensin 1
NCBI Official Synonym Full Names
defensin, alpha 1B
NCBI Protein Information
neutrophil defensin 1
UniProt Protein Name
Neutrophil defensin 1
UniProt Synonym Protein Names
Defensin, alpha 1; HNP-1; HP-1; HP1
UniProt Synonym Gene Names
UniProt Entry Name
DEF1_HUMAN
NCBI Summary for DEFA1
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
UniProt Comments for DEFA1
Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.2 PublicationsManual assertion based on experiment in:Ref.13
Research Articles on DEFA1
Precautions
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Disclaimer
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Products associated with DEFA1 elisa kit
Pathways associated with DEFA1 elisa kit
Diseases associated with DEFA1 elisa kit
Organs/Tissues associated with DEFA1 elisa kit
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