NP_001916.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,504 Da
NCBI Official Full Name
neutrophil defensin 4 preproprotein
NCBI Official Synonym Full Names
defensin, alpha 4, corticostatin
NCBI Protein Information
neutrophil defensin 4; corticostatin; defensin, alpha 4, preproprotein
UniProt Protein Name
Neutrophil defensin 4
UniProt Synonym Protein Names
Defensin, alpha 4; HNP-4; HP-4
UniProt Synonym Gene Names
UniProt Entry Name
DEF4_HUMAN
NCBI Summary for DEFA4
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Jul 2008]
UniProt Comments for DEFA4
DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8p23
Cellular Component: extracellular space; Golgi lumen; extracellular region
Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
Research Articles on DEFA4
Precautions
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Pathways associated with DEFA4 elisa kit
Diseases associated with DEFA4 elisa kit
Organs/Tissues associated with DEFA4 elisa kit
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