NP_116279.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
170,934 Da
NCBI Official Full Name
protein dispatched homolog 1
NCBI Official Synonym Full Names
dispatched homolog 1 (Drosophila)
NCBI Official Synonym Symbols
NCBI Protein Information
protein dispatched homolog 1; dispatched A
UniProt Protein Name
Protein dispatched homolog 1
UniProt Synonym Gene Names
UniProt Entry Name
DISP1_HUMAN
NCBI Summary for DISP1
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
UniProt Comments for DISP1
DISP1: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Belongs to the dispatched family.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: integral to membrane
Molecular Function: peptide transporter activity; hedgehog receptor activity
Biological Process: peptide transport; smoothened signaling pathway; dorsal/ventral pattern formation; patched ligand processing; embryonic pattern specification; determination of left/right symmetry
Research Articles on DISP1
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Diseases associated with DISP1 elisa kit
Organs/Tissues associated with DISP1 elisa kit
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