NP_001129389.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,031 Da
NCBI Official Full Name
dolichyldiphosphatase 1 isoform b
NCBI Official Synonym Full Names
dolichyldiphosphatase 1
NCBI Official Synonym Symbols
NCBI Protein Information
dolichyldiphosphatase 1; dolichyl pyrophosphate phosphatase 1; linked to Surfeit genes in Fugu rubripes 2
UniProt Protein Name
Dolichyldiphosphatase 1
UniProt Synonym Protein Names
Dolichyl pyrophosphate phosphatase 1
UniProt Synonym Gene Names
UniProt Entry Name
DOPP1_HUMAN
NCBI Summary for DOLPP1
A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
UniProt Comments for DOLPP1
DOLPP1: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. Belongs to the dolichyldiphosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.1.43; Endoplasmic reticulum; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, multi-pass; Hydrolase
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane
Molecular Function: dolichyldiphosphatase activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; lipid biosynthetic process; dolichyl diphosphate biosynthetic process; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
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Pathways associated with DOLPP1 elisa kit
Organs/Tissues associated with DOLPP1 elisa kit
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