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DOC2A elisa kit :: Human double C2-like domains, alpha ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9326036 DOC2A elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

double C2-like domains, alpha (DOC2A), ELISA Kit

 Also Known As   

Human double C2-like domains, alpha, DOC2A ELISA Kit

 Product Synonym Names    Human double C2-like domains; alpha (DOC2A) ELISA kit; double C2-like domains; alpha
 Product Gene Name   

DOC2A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604567
 3D Structure    ModBase 3D Structure for Q14183
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DOC2A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DOC2A purchase    MBS9326036 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the double C2-like domains, alpha (DOC2A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DOC2A. The ELISA analytical biochemical technique of the MBS9326036 kit is based on DOC2A antibody-DOC2A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DOC2A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DOC2A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for DOC2A. It may not necessarily be applicable to this product.
 NCBI GI #    530719513
 NCBI GeneID    8448
 NCBI Accession #    NP_001268991.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001282062.1 [Other Products]
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 UniProt Primary Accession #    Q14183 [Other Products]
 UniProt Secondary Accession #    Q6P4G4; Q7Z5G0; Q8IVX0 [Other Products]
 UniProt Related Accession #    Q14183 [Other Products]
 Molecular Weight    43,959 Da
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 NCBI Official Full Name    double C2-like domain-containing protein alpha
 NCBI Official Synonym Full Names    double C2-like domains, alpha
 NCBI Official Symbol    DOC2A [Similar Products]
 NCBI Official Synonym Symbols   
Doc2
[Similar Products]
 NCBI Protein Information    double C2-like domain-containing protein alpha; doc2-alpha
 UniProt Protein Name    Double C2-like domain-containing protein alpha
 Protein Family    Double C2-like domain-containing protein
 UniProt Gene Name    DOC2A [Similar Products]
 UniProt Synonym Gene Names    Doc2; Doc2-alpha [Similar Products]
 UniProt Entry Name    DOC2A_HUMAN
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 NCBI Summary for DOC2A    There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for DOC2A    DOC2A: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: neuron projection; synaptic vesicle membrane; lysosome; cell junction

Molecular Function: protein binding; calcium-dependent phospholipid binding; transporter activity

Biological Process: nervous system development; synaptic transmission; synaptic vesicle exocytosis; regulation of calcium ion-dependent exocytosis
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 Research Articles on DOC2A    1. Study analyzed Doc2alpha and Doc2beta and found that Doc2 responds to changes in [Ca2+], with markedly slower kinetics as compared to the cytosolic domain of syt I (syt), and operates on a timescale consistent with asynchronous neurotransmitter release.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DOC2A elisa kitDiseases associated with DOC2A elisa kit
 Reference Product  PubMed Publications
 UNC13B elisa kit  >6 publications with DOC2A and UNC13B
 DYNLT1 elisa kit  >1 publications with DOC2A and DYNLT1
 Disease Name  Pubmed Publications
 Syndrome Antibodies  >1 publications with DOC2A and Syndrome
 Seizures Antibodies  >1 publications with DOC2A and Seizures
 Nervous System Diseases Antibodies  >1 publications with DOC2A and Nervous System Diseases
Organs/Tissues associated with DOC2A elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with DOC2A and Brain
 Bone Antibodies  >2 publications with DOC2A and Bone
 Embryonic Tissue Antibodies  >1 publications with DOC2A and Embryonic Tissue
 Blood Antibodies  >1 publications with DOC2A and Blood
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