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DYNC1H1 elisa kit :: Human dynein, cytoplasmic 1, heavy chain 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS935354
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
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 Product Name   

dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), ELISA Kit

★Popular Item★
 Also Known As   

Human Cytoplasmic dynein 1 heavy chain 1, DYNC1H1 ELISA Kit

 Product Synonym Names    Human Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA kit; DHC1; DHC1a; DKFZp686P2245; DNCH1; DNCL; DNECL; DYHC; Dnchc1; HL-3; KIAA0325; p22; cytoplasmic dynein 1 heavy chain 1; dynein heavy chain; cytosolic; dynein; cytoplasmic; heavy polypeptide 1; dynein; c; dynein; cytoplasmic 1; heavy chain 1
 Product Gene Name   

DYNC1H1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS935354 Testing Data    Testing Data PDF
 OMIM    614563
 3D Structure    ModBase 3D Structure for Q14204
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human DYNC1H1. No significant cross-reactivity or interference between human DYNC1H1 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    18.75 pg/ml-1200 pg/ml.
 Sensitivity    The minimum detectable dose of human DYNC1H1 is typically less than 4.68pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DYNC1H1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DYNC1H1 purchase    MBS935354 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 18.75 pg/ml-1200 pg/ml in biological research samples containing DYNC1H1, with an estimated sensitivity of The minimum detectable dose of human DYNC1H1 is typically less than 4.68pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS935354 kit is based on DYNC1H1 antibody-DYNC1H1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DYNC1H1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DYNC1H1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for DYNC1H1 elisa kit

   Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for DYNC1H1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any DYNC1H1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for DYNC1H1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of DYNC1H1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of DYNC1H1 elisa kit    DYNC1H1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS935354. Click to request current manual
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NCBI/Uniprot data below describe general gene information for DYNC1H1. It may not necessarily be applicable to this product.
 NCBI GI #    33350932
 NCBI GeneID    1778
 NCBI Accession #    NP_001367.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001376.4 [Other Products]
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 UniProt Primary Accession #    Q14204 [Other Products]
 UniProt Secondary Accession #    Q6DKQ7; Q8WU28; Q92814; Q9Y4G5; B0I1R0 [Other Products]
 UniProt Related Accession #    Q14204 [Other Products]
 Molecular Weight    532,408 Da
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 NCBI Official Full Name    cytoplasmic dynein 1 heavy chain 1
 NCBI Official Synonym Full Names    dynein, cytoplasmic 1, heavy chain 1
 NCBI Official Symbol    DYNC1H1 [Similar Products]
 NCBI Official Synonym Symbols   
p22; DHC1; DNCL; DYHC; HL-3; DHC1a; DNCH1; DNECL; Dnchc1; SMALED1
[Similar Products]
 NCBI Protein Information    cytoplasmic dynein 1 heavy chain 1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy polypeptide 1
 UniProt Protein Name    Cytoplasmic dynein 1 heavy chain 1
 UniProt Synonym Protein Names   
Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic
 Protein Family    Cytoplasmic dynein
 UniProt Gene Name    DYNC1H1 [Similar Products]
 UniProt Synonym Gene Names    DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325 [Similar Products]
 UniProt Entry Name    DYHC1_HUMAN
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 NCBI Summary for DYNC1H1    Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
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 UniProt Comments for DYNC1H1    DNCH1: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Defects in DYNC1H1 are the cause of Charcot-Marie-Tooth disease type 2O (CMT2O). CMT2O is anaxonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Defects in DYNC1H1 are the cause of mental retardation autosomal dominant type 13 (MRD13). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD13 is associated with variable neuronal migration defects and mild dysmorphic features. Some patients may also show signs of peripheral neuropathy, such as abnormal gait and hyporeflexia. Defects in DYNC1H1 are the cause of spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMALED is characterized by muscle weakness predominantly affecting the proximal lower extremities. Belongs to the dynein heavy chain family.

Protein type: Motor; Motility/polarity/chemotaxis; Microtubule-binding

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: centrosome; microtubule; membrane; cytoplasmic dynein complex; cytosol; filopodium

Molecular Function: protein binding; ATPase activity; dynein light intermediate chain binding; microtubule motor activity; ATP binding

Biological Process: stress granule assembly; mitotic spindle organization and biogenesis; transport; metabolic process; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytoplasmic mRNA processing body assembly; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based movement

Disease: Charcot-marie-tooth Disease, Axonal, Type 2o; Spinal Muscular Atrophy, Lower Extremity-predominant, 1, Autosomal Dominant; Mental Retardation, Autosomal Dominant 13
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 Research Articles on DYNC1H1    1. This study demonistrated that DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DYNC1H1 elisa kitPathways associated with DYNC1H1 elisa kit
 Reference Product  PubMed Publications
 NDEL1 elisa kit  >1 publications with DYNC1H1 and NDEL1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
Diseases associated with DYNC1H1 elisa kitOrgans/Tissues associated with DYNC1H1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with DYNC1H1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >3 publications with DYNC1H1 and Congenital Abnormalities
 Atrophy Antibodies  >3 publications with DYNC1H1 and Atrophy
 Muscle Weakness Antibodies  >2 publications with DYNC1H1 and Muscle Weakness
 Pain Antibodies  >1 publications with DYNC1H1 and Pain
 Brain Diseases Antibodies  >1 publications with DYNC1H1 and Brain Diseases
 Neoplasms Antibodies  >1 publications with DYNC1H1 and Neoplasms
 Intellectual Disability Antibodies  >1 publications with DYNC1H1 and Intellectual Disability
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >4 publications with DYNC1H1 and Nerve
 Muscle Antibodies  >4 publications with DYNC1H1 and Muscle
 Ganglia Antibodies  >2 publications with DYNC1H1 and Ganglia
 Brain Antibodies  >2 publications with DYNC1H1 and Brain
 Trachea Antibodies  >1 publications with DYNC1H1 and Trachea
 Pancreas Antibodies  >1 publications with DYNC1H1 and Pancreas
 Eye Antibodies  >1 publications with DYNC1H1 and Eye
 Testis Antibodies  >1 publications with DYNC1H1 and Testis
 Embryonic Tissue Antibodies  >1 publications with DYNC1H1 and Embryonic Tissue
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