NP_001008707.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,861 Da
NCBI Official Full Name
echinoderm microtubule-associated protein-like 1 isoform a
NCBI Official Synonym Full Names
echinoderm microtubule associated protein like 1
NCBI Protein Information
echinoderm microtubule-associated protein-like 1; EMAP-1; huEMAP-1
UniProt Protein Name
Echinoderm microtubule-associated protein-like 1
UniProt Synonym Gene Names
UniProt Entry Name
EMAL1_HUMAN
NCBI Summary for EML1
Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EML1
EML1: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Belongs to the WD repeat EMAP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Cytoskeletal
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: microtubule; microtubule associated complex; perinuclear region of cytoplasm; cytosol
Molecular Function: tubulin binding; protein binding; microtubule binding; calcium ion binding
Biological Process: mitotic spindle organization and biogenesis; neuroblast proliferation; hemopoietic progenitor cell differentiation; brain development; microtubule cytoskeleton organization and biogenesis
Research Articles on EML1
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Diseases associated with EML1 elisa kit
Organs/Tissues associated with EML1 elisa kit
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