NP_001124397.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,866 Da
NCBI Official Full Name
HERV-W_7q21.2 provirus ancestral Env polyprotein
NCBI Official Synonym Full Names
endogenous retrovirus group W, member 1
NCBI Official Synonym Symbols
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV [Similar Products]
NCBI Protein Information
HERV-W_7q21.2 provirus ancestral Env polyprotein; env-W; enverin; syncytin A; syncytin-1; envelope protein; envelope glycoprotein; HERV-W Env glycoprotein; HERV-W envelope protein; HERV-7q envelope protein; envelope polyprotein gPr73; HERV-tryptophan envelope protein; endogenous retrovirus group W member 1; HERV-W{7q21.1} provirus ancestral Env polyprotein; endogenous retroviral family W, env(C7), member 1; human endogenous retrovirus W envC7-1 envelope protein
UniProt Protein Name
Syncytin-1
UniProt Synonym Protein Names
Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; SyncytinCleaved into the following 2 chains:Surface protein; SUAlternative name(s):gp50
UniProt Synonym Gene Names
UniProt Entry Name
SYCY1_HUMAN
NCBI Summary for ERVWE1
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for ERVWE1
ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: plasma membrane; integral to membrane; viral envelope
Biological Process: anatomical structure morphogenesis; syncytium formation
Research Articles on ERVWE1
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