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EOMES elisa kit :: Human eomesodermin homolog (Xenopus laevis) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9336863 EOMES elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

eomesodermin homolog (Xenopus laevis), ELISA Kit

 Also Known As   

Human Eomesodermin homolog, EOMES ELISA Kit

 Product Synonym Names    Human Eomesodermin homolog (EOMES) ELISA kit; TBR2; eomesodermin; t box; brain; 2; eomesodermin homolog (Xenopus laevis)
 Product Gene Name   

EOMES elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604615
 3D Structure    ModBase 3D Structure for O95936
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of EOMES elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EOMES purchase    MBS9336863 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the eomesodermin homolog (Xenopus laevis) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EOMES. The ELISA analytical biochemical technique of the MBS9336863 kit is based on EOMES antibody-EOMES antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EOMES antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EOMES. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for EOMES. It may not necessarily be applicable to this product.
 NCBI GI #    499591691
 NCBI GeneID    8320
 NCBI Accession #    NP_001265111.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278182.1 [Other Products]
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 UniProt Primary Accession #    O95936 [Other Products]
 UniProt Secondary Accession #    Q8TAZ2; Q9UPM7; B7Z4I2; B7ZA51; G3XAI5 [Other Products]
 UniProt Related Accession #    O95936 [Other Products]
 Molecular Weight    72,732 Da
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 NCBI Official Full Name    eomesodermin homolog isoform 1
 NCBI Official Synonym Full Names    eomesodermin
 NCBI Official Symbol    EOMES [Similar Products]
 NCBI Official Synonym Symbols   
TBR2
[Similar Products]
 NCBI Protein Information    eomesodermin homolog; T-box brain protein 2
 UniProt Protein Name    Eomesodermin homolog
 UniProt Synonym Protein Names   
T-box brain protein 2; T-brain-2; TBR-2
 Protein Family    Eomesodermin
 UniProt Gene Name    EOMES [Similar Products]
 UniProt Synonym Gene Names    TBR2; T-brain-2; TBR-2 [Similar Products]
 UniProt Entry Name    EOMES_HUMAN
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 NCBI Summary for EOMES    This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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 UniProt Comments for EOMES    EOMES: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4. Expressed in CD8+ T-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 3p24.1

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: CD8-positive, alpha-beta T cell differentiation during immune response; transcription, DNA-dependent; regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; olfactory bulb development; endodermal cell fate specification; stem cell maintenance; cerebral cortex regionalization; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation; cerebral cortex neuron differentiation; cardioblast differentiation; mesoderm formation; endoderm formation; interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; brain development; positive regulation of cell differentiation
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 Research Articles on EOMES    1. CD127 is downregulated at a transcriptional level in memory CD8 T cells in association with upregulation of Eomes expression in HIV infected patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with EOMES elisa kitDiseases associated with EOMES elisa kit
 Products by Pathway  Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >10 publications with EOMES and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >7 publications with EOMES and Nervous System Diseases
 Inflammation Antibodies  >3 publications with EOMES and Inflammation
 Head and Neck Neoplasms Antibodies  >3 publications with EOMES and Head and Neck Neoplasms
 Musculoskeletal Abnormalities Antibodies  >3 publications with EOMES and Musculoskeletal Abnormalities
 Ataxia Antibodies  >1 publications with EOMES and Ataxia
 Seizures, Febrile Antibodies  >1 publications with EOMES and Seizures, Febrile
 Seizures Antibodies  >1 publications with EOMES and Seizures
 Memory Disorders Antibodies  >1 publications with EOMES and Memory Disorders
 Epilepsy Antibodies  >1 publications with EOMES and Epilepsy
Organs/Tissues associated with EOMES elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >51 publications with EOMES and Brain
 Embryonic Tissue Antibodies  >31 publications with EOMES and Embryonic Tissue
 Eye Antibodies  >13 publications with EOMES and Eye
 Uterus Antibodies  >3 publications with EOMES and Uterus
 Testis Antibodies  >1 publications with EOMES and Testis
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