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EPS8 elisa kit :: Human epidermal growth factor receptor pathway substrate 8 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9343062 EPS8 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

epidermal growth factor receptor pathway substrate 8 (EPS8), ELISA Kit

★Popular Item★
 Also Known As   

Human Epidermal growth factor receptor kinase substrate 8, EPS8 ELISA Kit

 Product Synonym Names    Human Epidermal growth factor receptor kinase substrate 8 (EPS8) ELISA kit; epidermal growth factor receptor pathway substrate 8
 Product Gene Name   

EPS8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600206
 3D Structure    ModBase 3D Structure for Q12929
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.25 ng/ml - 8 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of EPS8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EPS8 purchase    MBS9343062 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the epidermal growth factor receptor pathway substrate 8 (EPS8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ng/ml - 8 ng/ml in biological research samples containing EPS8, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9343062 kit is based on EPS8 antibody-EPS8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EPS8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EPS8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for EPS8 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of EPS8 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9343062. Click to request current manual
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NCBI/Uniprot data below describe general gene information for EPS8. It may not necessarily be applicable to this product.
 NCBI GI #    56682953
 NCBI GeneID    2059
 NCBI Accession #    NP_004438.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004447.5 [Other Products]
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 UniProt Primary Accession #    Q12929 [Other Products]
 UniProt Secondary Accession #    Q8N6J0; A6NMC3; A8K6W2; A8KA66 [Other Products]
 UniProt Related Accession #    Q12929 [Other Products]
 Molecular Weight    91,882 Da
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 NCBI Official Full Name    epidermal growth factor receptor kinase substrate 8
 NCBI Official Synonym Full Names    epidermal growth factor receptor pathway substrate 8
 NCBI Official Symbol    EPS8 [Similar Products]
 NCBI Protein Information    epidermal growth factor receptor kinase substrate 8
 UniProt Protein Name    Epidermal growth factor receptor kinase substrate 8
 Protein Family    Epidermal growth factor receptor kinase substrate
 UniProt Gene Name    EPS8 [Similar Products]
 UniProt Entry Name    EPS8_HUMAN
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 NCBI Summary for EPS8    This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPS8    EPS8: an adaptor protein that is an epidermal growth factor receptor (EGFR) substrate. Enhances EGF-dependent mitogenic signals. Member of a family of actin barbing and capping proteins. Promotes filopodial protrusions. Complexes containing Eps8/Abi1/PI3K/Sos-1 mediate Rac activation following EGFR signaling. Involved in endocytosis of EGFR by binding to the Rab5-specific GTPase activating protein USP6N. Binds to IRSp53, which binds small the small GTPases Rac and Cdc42, and which regulates actin dynamics. Involved in the actin-remodeling activity in cultured cerebellar neurons. Regulates the actin-remodeling activities of NMDA and ethanol in neurons. Eps8 knockout mice show behavioral resistance to ethanol. Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: stereocilium; growth cone; postsynaptic density; cell cortex; cell junction; vesicle; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; SH3/SH2 adaptor activity; Rac GTPase binding; actin binding

Biological Process: actin crosslink formation; epidermal growth factor receptor signaling pathway; actin filament bundle formation; positive regulation of signal transduction; adult locomotory behavior; Rac protein signal transduction; behavioral response to ethanol; signal transduction; regulation of cell shape; cell proliferation; actin cytoskeleton reorganization; regulation of actin filament length; barbed-end actin filament capping; exit from mitosis

Disease: Deafness, Autosomal Recessive 102
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 Research Articles on EPS8    1. Eps8 functions as a key coordinator in the interplay between FGFR signalling and trafficking.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPS8 elisa kitPathways associated with EPS8 elisa kit
 Reference Product  PubMed Publications
 SRC elisa kit  >36 publications with EPS8 and SRC
 ABI1 elisa kit  >23 publications with EPS8 and ABI1
 EGFR elisa kit  >16 publications with EPS8 and EGFR
 SOS1 elisa kit  >15 publications with EPS8 and SOS1
 BAIAP2 elisa kit  >7 publications with EPS8 and BAIAP2
 USP6NL elisa kit  >4 publications with EPS8 and USP6NL
 SHC1 elisa kit  >4 publications with EPS8 and SHC1
 SHB elisa kit  >2 publications with EPS8 and SHB
 DVL1 elisa kit  >1 publications with EPS8 and DVL1
 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
Diseases associated with EPS8 elisa kitOrgans/Tissues associated with EPS8 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >26 publications with EPS8 and Neoplasms
 Carcinoma Antibodies  >10 publications with EPS8 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with EPS8 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >5 publications with EPS8 and Disease Models, Animal
 Breast Neoplasms Antibodies  >4 publications with EPS8 and Breast Neoplasms
 Nervous System Diseases Antibodies  >4 publications with EPS8 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with EPS8 and Brain Diseases
 Neoplasm Metastasis Antibodies  >3 publications with EPS8 and Neoplasm Metastasis
 Colorectal Neoplasms Antibodies  >3 publications with EPS8 and Colorectal Neoplasms
 Liver Diseases Antibodies  >2 publications with EPS8 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with EPS8 and Brain
 Blood Antibodies  >12 publications with EPS8 and Blood
 Testis Antibodies  >10 publications with EPS8 and Testis
 Embryonic Tissue Antibodies  >4 publications with EPS8 and Embryonic Tissue
 Liver Antibodies  >4 publications with EPS8 and Liver
 Intestine Antibodies  >3 publications with EPS8 and Intestine
 Muscle Antibodies  >3 publications with EPS8 and Muscle
 Lung Antibodies  >2 publications with EPS8 and Lung
 Vascular Antibodies  >2 publications with EPS8 and Vascular
 Ascites Antibodies  >2 publications with EPS8 and Ascites
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