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EREG elisa kit :: Human epiregulin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS904261
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

epiregulin (EREG), ELISA Kit

 Also Known As   

Human epiregulin, EREG ELISA Kit

 Product Synonym Names    Human epiregulin (EREG) ELISA kit; ER; ; epiregulin
 Product Gene Name   

EREG elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS904261 Testing Data    Testing Data PDF
 OMIM    602061
 3D Structure    ModBase 3D Structure for O14944
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human EREG. No significant cross-reactivity or interference between human EREG and analogues was observed.
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 Samples    Serum, plasma, cell culture supernates, tissue homogenates.
 Assay Type    Sandwich (Quantitative)
 Detection Range    15.6 pg/ml-1000 pg/ml.
 Sensitivity    3.9 pg/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of EREG elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EREG purchase    MBS904261 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the epiregulin (EREG) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6 pg/ml-1000 pg/ml in biological research samples containing EREG, with an estimated sensitivity of 3.9 pg/ml. The ELISA analytical biochemical technique of the MBS904261 kit is based on EREG antibody-EREG antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EREG antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EREG. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernates, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for EREG elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for EREG has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any EREG present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for EREG is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of EREG bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of EREG elisa kit    EREG elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS904261
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NCBI/Uniprot data below describe general gene information for EREG. It may not necessarily be applicable to this product.
 NCBI GI #    4557567
 NCBI GeneID    2069
 NCBI Accession #    NP_001423.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001432.2 [Other Products]
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 UniProt Primary Accession #    O14944 [Other Products]
 UniProt Secondary Accession #    Q6FH69; B2RC66 [Other Products]
 UniProt Related Accession #    O14944 [Other Products]
 Molecular Weight    19,044 Da
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 NCBI Official Full Name    proepiregulin preproprotein
 NCBI Official Synonym Full Names    epiregulin
 NCBI Official Symbol    EREG [Similar Products]
 NCBI Official Synonym Symbols   
ER
[Similar Products]
 NCBI Protein Information    proepiregulin
 UniProt Protein Name    Proepiregulin
 Protein Family    Proepiregulin
 UniProt Gene Name    EREG [Similar Products]
 UniProt Synonym Gene Names    EPR [Similar Products]
 UniProt Entry Name    EREG_HUMAN
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 NCBI Summary for EREG    Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EREG    Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane; extracellular region

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: response to peptide hormone stimulus; nerve growth factor receptor signaling pathway; wound healing; activation of MAPK activity; positive regulation of interleukin-6 biosynthetic process; positive regulation of smooth muscle cell proliferation; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; primary follicle stage, oogenesis; positive regulation of fibroblast proliferation; positive regulation of epidermal growth factor receptor activity; cell-cell signaling; positive regulation of innate immune response; positive regulation of cell proliferation; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; keratinocyte differentiation; ovulation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication; positive regulation of phosphorylation
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 Research Articles on EREG    1. Epiregulin is a transcriptional target of TSC2 (tuberin).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EREG elisa kitPathways associated with EREG elisa kit
 Reference Product  PubMed Publications
 EGFR elisa kit  >22 publications with EREG and EGFR
 ERBB4 elisa kit  >1 publications with EREG and ERBB4
 Products by Pathway  Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 GRB2 Events In ERBB2 Signaling Pathway antibodies  GRB2 Events In ERBB2 Signaling Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 PI3K Events In ERBB2 Signaling Pathway antibodies  PI3K Events In ERBB2 Signaling Pathway Diagram
 PI3K Events In ERBB4 Signaling Pathway antibodies  PI3K Events In ERBB4 Signaling Pathway Diagram
 SHC1 Events In ERBB2 Signaling Pathway antibodies  SHC1 Events In ERBB2 Signaling Pathway Diagram
Diseases associated with EREG elisa kitOrgans/Tissues associated with EREG elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with EREG and Neoplasms
 Gastrointestinal Diseases Antibodies  >9 publications with EREG and Gastrointestinal Diseases
 Gastrointestinal Neoplasms Antibodies  >8 publications with EREG and Gastrointestinal Neoplasms
 Colorectal Neoplasms Antibodies  >8 publications with EREG and Colorectal Neoplasms
 Carcinoma Antibodies  >7 publications with EREG and Carcinoma
 Breast Neoplasms Antibodies  >6 publications with EREG and Breast Neoplasms
 Liver Neoplasms Antibodies  >5 publications with EREG and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >5 publications with EREG and Neoplasm Metastasis
 Drug Toxicity Antibodies  >4 publications with EREG and Drug Toxicity
 Disease Models, Animal Antibodies  >4 publications with EREG and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with EREG and Blood
 Lung Antibodies  >6 publications with EREG and Lung
 Liver Antibodies  >6 publications with EREG and Liver
 Skin Antibodies  >5 publications with EREG and Skin
 Muscle Antibodies  >4 publications with EREG and Muscle
 Lymph Node Antibodies  >1 publications with EREG and Lymph Node
 Kidney Antibodies  >1 publications with EREG and Kidney
 Intestine Antibodies  >1 publications with EREG and Intestine
 Mouth Antibodies  >1 publications with EREG and Mouth
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