NP_001185730.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,652 Da
NCBI Official Full Name
eukaryotic translation initiation factor 4 gamma 3 isoform 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4 gamma, 3
NCBI Protein Information
eukaryotic translation initiation factor 4 gamma 3; eIF-4-gamma 3; eIF-4-gamma II
UniProt Protein Name
Eukaryotic translation initiation factor 4 gamma 3
UniProt Synonym Protein Names
eIF-4-gamma II; eIF4GII
UniProt Synonym Gene Names
UniProt Entry Name
IF4G3_HUMAN
UniProt Comments for EIF4G3
EIF4G3: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Belongs to the eIF4G family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation; RNA-binding; Translation initiation
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: eukaryotic translation initiation factor 4F complex; cytosol
Molecular Function: translation factor activity, nucleic acid binding; translation initiation factor activity; RNA cap binding
Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; translational initiation; regulation of translational initiation
Research Articles on EIF4G3
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Products associated with EIF4G3 elisa kit
Pathways associated with EIF4G3 elisa kit
Organs/Tissues associated with EIF4G3 elisa kit
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