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ERCC1 elisa kit :: Human excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS701478
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $550 +1 FREE 8GB USB
96-Strip-Wells  /  $795 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,890 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,465 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), ELISA Kit

 Also Known As   

Human excision repair cross-complementation group 1, ERCC1 ELISA Kit

 Product Synonym Names    Human excision repair cross-complementation group 1 (ERCC1) ELISA Kit; COFS4; UV20; DNA excision repair protein; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency; complementation group 1 (includes overlapping antisense sequence)
 Product Gene Name   

ERCC1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS701478 Testing Data    Testing Data PDF
 OMIM    gene 610758
 3D Structure    ModBase 3D Structure for P07992
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human ERCC1. No significant cross-reactivity or interference between human ERCC1 and analogues was observed.
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 Samples    Serum, cell lysates.
 Assay Type    Sandwich (Quantitative)
 Detection Range    31.25 pg/ml -2000 pg/ml.
 Sensitivity    7.81 pg/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ERCC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ERCC1 purchase    MBS701478 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.25 pg/ml -2000 pg/ml in biological research samples containing ERCC1, with an estimated sensitivity of 7.81 pg/ml. The ELISA analytical biochemical technique of the MBS701478 kit is based on ERCC1 antibody-ERCC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERCC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERCC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ERCC1 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ERCC1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ERCC1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ERCC1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ERCC1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of ERCC1 elisa kit    ERCC1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS701478. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ERCC1. It may not necessarily be applicable to this product.
 NCBI GI #    260593725
 NCBI GeneID    2067
 NCBI Accession #    NP_001159521.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166049.1 [Other Products]
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 UniProt Primary Accession #    P07992 [Other Products]
 UniProt Secondary Accession #    Q7Z7F5; Q96S40; B2RC01; B3KRR0 [Other Products]
 UniProt Related Accession #    P07992 [Other Products]
 Molecular Weight    32,562 Da
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 NCBI Official Full Name    DNA excision repair protein ERCC-1 isoform 3
 NCBI Official Synonym Full Names    excision repair cross-complementation group 1
 NCBI Official Symbol    ERCC1 [Similar Products]
 NCBI Official Synonym Symbols   
UV20; COFS4; RAD10
[Similar Products]
 NCBI Protein Information    DNA excision repair protein ERCC-1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
 UniProt Protein Name    DNA excision repair protein ERCC-1
 Protein Family    DNA excision repair protein
 UniProt Gene Name    ERCC1 [Similar Products]
 UniProt Entry Name    ERCC1_HUMAN
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 NCBI Summary for ERCC1    The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
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 UniProt Comments for ERCC1    Function: Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.1 PublicationManual assertion based on experiment in:Ref.12
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 Research Articles on ERCC1    1. Data suggest that excision repair cross-complementation group 1 enzyme (ERCC1) may represent a potential predictive marker for platinum-based treatment in bladder cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ERCC1 elisa kitPathways associated with ERCC1 elisa kit
 Reference Product  PubMed Publications
 ERCC2 elisa kit  >193 publications with ERCC1 and ERCC2
 XPA elisa kit  >167 publications with ERCC1 and XPA
 XPC elisa kit  >100 publications with ERCC1 and XPC
 ERCC4 elisa kit  >76 publications with ERCC1 and ERCC4
 ERCC5 elisa kit  >51 publications with ERCC1 and ERCC5
 ERCC3 elisa kit  >30 publications with ERCC1 and ERCC3
 RAD23B elisa kit  >11 publications with ERCC1 and RAD23B
 POLD1 elisa kit  >2 publications with ERCC1 and POLD1
 GTF2H1 elisa kit  >2 publications with ERCC1 and GTF2H1
 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Dual Incision Reaction In GG-NER Pathway antibodies  Dual Incision Reaction In GG-NER Pathway Diagram
 Dual Incision Reaction In TC-NER Pathway antibodies  Dual Incision Reaction In TC-NER Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Formation Of Incision Complex In GG-NER Pathway antibodies  Formation Of Incision Complex In GG-NER Pathway Diagram
 Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway antibodies  Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway Diagram
 Global Genomic NER (GG-NER) Pathway antibodies  Global Genomic NER (GG-NER) Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
Diseases associated with ERCC1 elisa kitOrgans/Tissues associated with ERCC1 elisa kit
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >394 publications with ERCC1 and Lung Neoplasms
 Carcinoma, Non-Small-Cell Lung Antibodies  >303 publications with ERCC1 and Carcinoma, Non-Small-Cell Lung
 Adenocarcinoma Antibodies  >172 publications with ERCC1 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >117 publications with ERCC1 and Carcinoma, Squamous Cell
 Ovarian Neoplasms Antibodies  >104 publications with ERCC1 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >77 publications with ERCC1 and Breast Neoplasms
 Stomach Neoplasms Antibodies  >61 publications with ERCC1 and Stomach Neoplasms
 Neoplasm Metastasis Antibodies  >61 publications with ERCC1 and Neoplasm Metastasis
 Neoplasms, Germ Cell and Embryonal Antibodies  >50 publications with ERCC1 and Neoplasms, Germ Cell and Embryonal
 Neoplasms, Experimental Antibodies  >47 publications with ERCC1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with ERCC1 and Bone
 Connective Tissue Antibodies  >4 publications with ERCC1 and Connective Tissue
 Heart Antibodies  >3 publications with ERCC1 and Heart
 Muscle Antibodies  >3 publications with ERCC1 and Muscle
 Brain Antibodies  >3 publications with ERCC1 and Brain
 Vascular Antibodies  >2 publications with ERCC1 and Vascular
 Embryonic Tissue Antibodies  >2 publications with ERCC1 and Embryonic Tissue
 Ear Antibodies  >1 publications with ERCC1 and Ear
 Kidney Antibodies  >1 publications with ERCC1 and Kidney
 Umbilical Cord Antibodies  >1 publications with ERCC1 and Umbilical Cord
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