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EXO1 elisa kit :: Human exonuclease 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9341026 EXO1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

exonuclease 1 (EXO1), ELISA Kit

 Also Known As   

Human Exonuclease 1, EXO1 ELISA Kit

 Product Synonym Names    Human Exonuclease 1 (EXO1) ELISA kit; RP11-553N16.2; HEX1; hExoI; rad2 nuclease family member; homolog of S. cerevisiae exonuclease 1; exonuclease 1
 Product Gene Name   

EXO1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    606063
 3D Structure    ModBase 3D Structure for Q9UQ84
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of EXO1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EXO1 purchase    MBS9341026 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the exonuclease 1 (EXO1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EXO1. The ELISA analytical biochemical technique of the MBS9341026 kit is based on EXO1 antibody-EXO1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EXO1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EXO1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for EXO1. It may not necessarily be applicable to this product.
 NCBI GI #    284055276
 NCBI GeneID    9156
 NCBI Accession #    NP_003677.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_003686.4 [Other Products]
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 UniProt Primary Accession #    Q9UQ84 [Other Products]
 UniProt Secondary Accession #    O60545; O75214; O75466; Q5T396; Q96IJ1; Q9UG38; Q9UNW0 [Other Products]
 UniProt Related Accession #    Q9UQ84 [Other Products]
 Molecular Weight    94,103 Da
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 NCBI Official Full Name    exonuclease 1 isoform a
 NCBI Official Synonym Full Names    exonuclease 1
 NCBI Official Symbol    EXO1 [Similar Products]
 NCBI Official Synonym Symbols   
HEX1; hExoI
[Similar Products]
 NCBI Protein Information    exonuclease 1; hExo1; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
 UniProt Protein Name    Exonuclease 1
 UniProt Synonym Protein Names   
Exonuclease I; hExoI
 Protein Family    Exonuclease
 UniProt Gene Name    EXO1 [Similar Products]
 UniProt Synonym Gene Names    EXOI; HEX1; hExo1; hExoI [Similar Products]
 UniProt Entry Name    EXO1_HUMAN
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 NCBI Summary for EXO1    This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EXO1    EXO1: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.-.-; Hydrolase

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: nucleoplasm; nucleus

Molecular Function: 5'-3' exonuclease activity; protein binding; structure-specific DNA binding; double-stranded DNA specific 5'-3' exodeoxyribonuclease activity; DNA binding; single-stranded DNA specific 5'-3' exodeoxyribonuclease activity; 5'-3' exodeoxyribonuclease activity; metal ion binding; exonuclease activity; ribonuclease H activity; flap endonuclease activity

Biological Process: humoral immune response mediated by circulating immunoglobulin; mismatch repair; meiotic cell cycle; somatic hypermutation of immunoglobulin genes; isotype switching; DNA repair; DNA catabolic process, exonucleolytic; DNA catabolic process, endonucleolytic; DNA recombination
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 Research Articles on EXO1    1. This study reports that, contrary to earlier reports, and unlike the catalytic site mutant D173A, the EXO1 E109K variant resembled the wild-type enzyme on all tested substrates.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EXO1 elisa kitPathways associated with EXO1 elisa kit
 Reference Product  PubMed Publications
 MSH2 elisa kit  >39 publications with EXO1 and MSH2
 MLH1 elisa kit  >28 publications with EXO1 and MLH1
 PCNA elisa kit  >16 publications with EXO1 and PCNA
 MSH3 elisa kit  >12 publications with EXO1 and MSH3
 PMS2 elisa kit  >3 publications with EXO1 and PMS2
 Products by Pathway  Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
Diseases associated with EXO1 elisa kitOrgans/Tissues associated with EXO1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >36 publications with EXO1 and Neoplasms
 Gastrointestinal Diseases Antibodies  >19 publications with EXO1 and Gastrointestinal Diseases
 Colorectal Neoplasms Antibodies  >18 publications with EXO1 and Colorectal Neoplasms
 Carcinoma Antibodies  >11 publications with EXO1 and Carcinoma
 Adenocarcinoma Antibodies  >7 publications with EXO1 and Adenocarcinoma
 Ataxia Antibodies  >6 publications with EXO1 and Ataxia
 Lung Neoplasms Antibodies  >5 publications with EXO1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >4 publications with EXO1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >3 publications with EXO1 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >2 publications with EXO1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >7 publications with EXO1 and Testis
 Lung Antibodies  >6 publications with EXO1 and Lung
 Brain Antibodies  >6 publications with EXO1 and Brain
 Bone Antibodies  >5 publications with EXO1 and Bone
 Liver Antibodies  >4 publications with EXO1 and Liver
 Bone Marrow Antibodies  >3 publications with EXO1 and Bone Marrow
 Adrenal Gland Antibodies  >3 publications with EXO1 and Adrenal Gland
 Thymus Antibodies  >3 publications with EXO1 and Thymus
 Stomach Antibodies  >3 publications with EXO1 and Stomach
 Kidney Antibodies  >3 publications with EXO1 and Kidney
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