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FDPS elisa kit :: Human farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9336350 FDPS elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) (FDPS), ELISA Kit

★Popular Item★
 Also Known As   

Human Farnesyl pyrophosphate synthase, FDPS ELISA Kit

 Product Synonym Names    Human Farnesyl pyrophosphate synthase (FDPS) ELISA kit; FPPS; FPS; FPP synthetase; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase; geranyltranstransferase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase; dimethylallyltranstransferase; geranyltranstransferase)
 Product Gene Name   

FDPS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    134629
 3D Structure    ModBase 3D Structure for P14324
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich
 Detection Range    0.25 ng/ml - 8 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FDPS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FDPS purchase    MBS9336350 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) (FDPS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ng/ml - 8 ng/ml in biological research samples containing FDPS, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9336350 kit is based on FDPS antibody-FDPS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FDPS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FDPS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for FDPS elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of FDPS (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9336350. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FDPS. It may not necessarily be applicable to this product.
 NCBI GI #    209571582
 NCBI GeneID    2224
 NCBI Accession #    NP_001129293.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135821.1 [Other Products]
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 UniProt Primary Accession #    P14324 [Other Products]
 UniProt Secondary Accession #    Q96G29; D3DV91; E9PCI9 [Other Products]
 UniProt Related Accession #    P14324 [Other Products]
 Molecular Weight    48,275 Da
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 NCBI Official Full Name    farnesyl pyrophosphate synthase isoform a
 NCBI Official Synonym Full Names    farnesyl diphosphate synthase
 NCBI Official Symbol    FDPS [Similar Products]
 NCBI Official Synonym Symbols   
FPS; FPPS
[Similar Products]
 NCBI Protein Information    farnesyl pyrophosphate synthase; FPP synthase; FPP synthetase; geranyltranstransferase; dimethylallyltranstransferase; (2E,6E)-farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
 UniProt Protein Name    Farnesyl pyrophosphate synthase
 UniProt Synonym Protein Names   
(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Geranyltranstransferase
 Protein Family    Farnesyl pyrophosphate synthase
 UniProt Gene Name    FDPS [Similar Products]
 UniProt Synonym Gene Names    FPS; KIAA1293; FPP synthase; FPS [Similar Products]
 UniProt Entry Name    FPPS_HUMAN
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 NCBI Summary for FDPS    This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
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 UniProt Comments for FDPS    FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family.

Protein type: Motility/polarity/chemotaxis; Transferase; EC 2.5.1.10; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.1

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol

Molecular Function: geranyltranstransferase activity; dimethylallyltranstransferase activity; metal ion binding

Biological Process: viral reproduction; geranyl diphosphate biosynthetic process; farnesyl diphosphate biosynthetic process; cholesterol biosynthetic process
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 Research Articles on FDPS    1. The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiinfective drug leads.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FDPS elisa kitDiseases associated with FDPS elisa kit
 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >47 publications with FDPS and Cardiovascular Diseases
 Blood Coagulation Disorders Antibodies  >36 publications with FDPS and Blood Coagulation Disorders
 Hemorrhage Antibodies  >20 publications with FDPS and Hemorrhage
 Neoplasms Antibodies  >18 publications with FDPS and Neoplasms
 Myocardial Infarction Antibodies  >16 publications with FDPS and Myocardial Infarction
 Myocardial Ischemia Antibodies  >13 publications with FDPS and Myocardial Ischemia
 Nervous System Diseases Antibodies  >13 publications with FDPS and Nervous System Diseases
 Liver Diseases Antibodies  >10 publications with FDPS and Liver Diseases
 Brain Diseases Antibodies  >10 publications with FDPS and Brain Diseases
 Inflammation Antibodies  >10 publications with FDPS and Inflammation
Organs/Tissues associated with FDPS elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >99 publications with FDPS and Blood
 Bone Antibodies  >35 publications with FDPS and Bone
 Liver Antibodies  >29 publications with FDPS and Liver
 Mouth Antibodies  >23 publications with FDPS and Mouth
 Vascular Antibodies  >18 publications with FDPS and Vascular
 Heart Antibodies  >13 publications with FDPS and Heart
 Lung Antibodies  >9 publications with FDPS and Lung
 Kidney Antibodies  >9 publications with FDPS and Kidney
 Muscle Antibodies  >7 publications with FDPS and Muscle
 Brain Antibodies  >6 publications with FDPS and Brain
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