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FBN2 elisa kit :: Human fibrillin 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS923618 FBN2 elisa kit
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

fibrillin 2 (FBN2), ELISA Kit

★Popular Item★
 Also Known As   

Human Fibrillin-2, FBN2 ELISA Kit

 Product Synonym Names    Human Fibrillin-2 (FBN2) ELISA kit; CCA; DA9; fibrillin 5; fibrillin 2
 Product Gene Name   

FBN2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    612570
 3D Structure    ModBase 3D Structure for P35556
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human FBN2. No significant cross-reactivity or interference between human FBN2 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates.
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.625 ng/ml -40 ng/ml.
 Sensitivity    0.156 ng/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FBN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FBN2 purchase    MBS923618 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the fibrillin 2 (FBN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml -40 ng/ml in biological research samples containing FBN2, with an estimated sensitivity of 0.156 ng/ml. The ELISA analytical biochemical technique of the MBS923618 kit is based on FBN2 antibody-FBN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FBN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FBN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FBN2 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FBN2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FBN2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FBN2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FBN2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Sample Manual Insert of MBS923618. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FBN2. It may not necessarily be applicable to this product.
 NCBI GI #    66346695
 NCBI GeneID    2201
 NCBI Accession #    NP_001990.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001999.3 [Other Products]
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 UniProt Primary Accession #    P35556 [Other Products]
 UniProt Secondary Accession #    Q59ES6; B4DU01 [Other Products]
 UniProt Related Accession #    P35556 [Other Products]
 Molecular Weight    314,775 Da
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 NCBI Official Full Name    fibrillin-2
 NCBI Official Synonym Full Names    fibrillin 2
 NCBI Official Symbol    FBN2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    fibrillin-2; fibrillin 5
 UniProt Protein Name    Fibrillin-2
 Protein Family    Fibrillin
 UniProt Gene Name    FBN2 [Similar Products]
 UniProt Entry Name    FBN2_HUMAN
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 NCBI Summary for FBN2    The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBN2    FBN2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Defects in FBN2 are the cause of distal arthrogryposis type 9 (DA9). A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA9 is a connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears. Belongs to the fibrillin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q23-q31

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region; microfibril

Molecular Function: protein binding; extracellular matrix structural constituent; calcium ion binding

Biological Process: positive regulation of osteoblast differentiation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; anatomical structure morphogenesis; positive regulation of bone mineralization; embryonic limb morphogenesis

Disease: Macular Degeneration, Early-onset; Arthrogryposis, Distal, Type 9
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 Research Articles on FBN2    1. Fibrillin mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FBN2 elisa kitDiseases associated with FBN2 elisa kit
 Reference Product  PubMed Publications
 FBN1 elisa kit  >29 publications with FBN2 and FBN1
 Disease Name  Pubmed Publications
 Congenital contractural arachnodactyly Antibodies  >29 publications with FBN2 and Congenital contractural arachnodactyly
 Nervous System Diseases Antibodies  >7 publications with FBN2 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with FBN2 and Brain Diseases
 Colorectal Neoplasms Antibodies  >3 publications with FBN2 and Colorectal Neoplasms
 Lung Neoplasms Antibodies  >2 publications with FBN2 and Lung Neoplasms
 Eye Abnormalities Antibodies  >2 publications with FBN2 and Eye Abnormalities
 Polycystic Ovary Syndrome Antibodies  >1 publications with FBN2 and Polycystic Ovary Syndrome
 Craniofacial Abnormalities Antibodies  >1 publications with FBN2 and Craniofacial Abnormalities
 Neoplasms, Experimental Antibodies  >1 publications with FBN2 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >1 publications with FBN2 and Drug Toxicity
Organs/Tissues associated with FBN2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >21 publications with FBN2 and Connective Tissue
 Skin Antibodies  >8 publications with FBN2 and Skin
 Muscle Antibodies  >7 publications with FBN2 and Muscle
 Ear Antibodies  >5 publications with FBN2 and Ear
 Bone Antibodies  >5 publications with FBN2 and Bone
 Embryonic Tissue Antibodies  >5 publications with FBN2 and Embryonic Tissue
 Kidney Antibodies  >4 publications with FBN2 and Kidney
 Eye Antibodies  >4 publications with FBN2 and Eye
 Lung Antibodies  >3 publications with FBN2 and Lung
 Vascular Antibodies  >2 publications with FBN2 and Vascular
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