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FGF14 elisa kit :: Human fibroblast growth factor 14 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS918979
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
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 Product Name   

fibroblast growth factor 14 (FGF14), ELISA Kit

★Popular Item★
 Also Known As   

Human Fibroblast growth factor 14, FGF14 ELISA Kit

 Product Synonym Names    Human Fibroblast growth factor 14 (FGF14) ELISA kit; RP11-397O8.6; FHF4; MGC119129; SCA27; bA397O8.2; fibroblast growth factor homologous factor 4; fibroblast growth factor 14
 Product Gene Name   

FGF14 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS918979 Testing Data    Testing Data PDF
 OMIM    gene 609307
 3D Structure    ModBase 3D Structure for Q92915
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human FGF14. No significant cross-reactivity or interference between human FGF14 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    23.5 pg/ml -1500 pg/ml.
 Sensitivity    The minimum detectable dose of human FGF14 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FGF14 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FGF14 purchase    MBS918979 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the fibroblast growth factor 14 (FGF14) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 23.5 pg/ml -1500 pg/ml in biological research samples containing FGF14, with an estimated sensitivity of The minimum detectable dose of human FGF14 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS918979 kit is based on FGF14 antibody-FGF14 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FGF14 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FGF14. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FGF14 elisa kit

   Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FGF14 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FGF14 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FGF14 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FGF14 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of FGF14 elisa kit    FGF14 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS918979. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FGF14. It may not necessarily be applicable to this product.
 NCBI GI #    4758368
 NCBI GeneID    2259
 NCBI Accession #    NP_004106.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004115.3 [Other Products]
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 UniProt Primary Accession #    Q92915 [Other Products]
 UniProt Secondary Accession #    Q86YN7; Q96QX6 [Other Products]
 UniProt Related Accession #    Q92915 [Other Products]
 Molecular Weight    28,462 Da
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 NCBI Official Full Name    fibroblast growth factor 14 isoform 1A
 NCBI Official Synonym Full Names    fibroblast growth factor 14
 NCBI Official Symbol    FGF14 [Similar Products]
 NCBI Official Synonym Symbols   
FHF4; FHF-4; SCA27; FGF-14
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 14; bA397O8.2; fibroblast growth factor homologous factor 4
 UniProt Protein Name    Fibroblast growth factor 14
 UniProt Synonym Protein Names   
Fibroblast growth factor homologous factor 4; FHF-4
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF14 [Similar Products]
 UniProt Synonym Gene Names    FHF4; FGF-14; FHF-4 [Similar Products]
 UniProt Entry Name    FGF14_HUMAN
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 NCBI Summary for FGF14    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF14    FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell development/differentiation

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular region; nucleus

Molecular Function: heparin binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: nervous system development; synaptic transmission; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; JNK cascade; signal transduction

Disease: Spinocerebellar Ataxia 27
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 Research Articles on FGF14    1. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FGF14 elisa kitDiseases associated with FGF14 elisa kit
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with FGF14 and Neoplasms
 Metaplasia Antibodies  >2 publications with FGF14 and Metaplasia
 Movement Disorders Antibodies  >2 publications with FGF14 and Movement Disorders
 Spinocerebellar ataxia 27 Antibodies  >2 publications with FGF14 and Spinocerebellar ataxia 27
 Necrosis Antibodies  >1 publications with FGF14 and Necrosis
 Drug Toxicity Antibodies  >1 publications with FGF14 and Drug Toxicity
Organs/Tissues associated with FGF14 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with FGF14 and Brain
 Nerve Antibodies  >6 publications with FGF14 and Nerve
 Muscle Antibodies  >1 publications with FGF14 and Muscle
 Testis Antibodies  >1 publications with FGF14 and Testis
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