NP_001138301.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,221 Da
NCBI Official Full Name
dimethylaniline monooxygenase
NCBI Official Synonym Full Names
flavin containing monooxygenase 5
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 5
UniProt Synonym Protein Names
Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5
UniProt Synonym Gene Names
UniProt Entry Name
FMO5_HUMAN
NCBI Summary for FMO5
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
UniProt Comments for FMO5
FMO5: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Belongs to the FMO family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: 1q21.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: FAD binding; NADP binding; flavin-containing monooxygenase activity
Research Articles on FMO5
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Pathways associated with FMO5 elisa kit
Diseases associated with FMO5 elisa kit
Organs/Tissues associated with FMO5 elisa kit
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