NP_004110.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
112,903 Da
NCBI Official Full Name
receptor-type tyrosine-protein kinase FLT3
NCBI Official Synonym Full Names
fms-related tyrosine kinase 3
NCBI Protein Information
receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III
UniProt Protein Name
Receptor-type tyrosine-protein kinase FLT3
UniProt Synonym Protein Names
FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135
UniProt Synonym Gene Names
UniProt Entry Name
FLT3_HUMAN
NCBI Summary for FLT3
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
UniProt Comments for FLT3
Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.11 PublicationsManual assertion based on experiment in:Ref.1
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.1 PublicationManual assertion based on experiment in:Ref.13
Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to dimerization and activation by autophosphorylation.2 PublicationsManual assertion based on experiment in:Ref.24
Research Articles on FLT3
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Products associated with FLT3 elisa kit
Pathways associated with FLT3 elisa kit
Diseases associated with FLT3 elisa kit
Disease Name |
Pubmed Publications |
Leukemia, Myeloid, Acute Antibodies |
>1730 publications with FLT3 and Leukemia, Myeloid, Acute |
Bone Marrow Diseases Antibodies |
>297 publications with FLT3 and Bone Marrow Diseases |
Cell Transformation, Neoplastic Antibodies |
>155 publications with FLT3 and Cell Transformation, Neoplastic |
Leukemia, Promyelocytic, Acute Antibodies |
>140 publications with FLT3 and Leukemia, Promyelocytic, Acute |
Necrosis Antibodies |
>123 publications with FLT3 and Necrosis |
Neoplasms, Experimental Antibodies |
>97 publications with FLT3 and Neoplasms, Experimental |
Inflammation Antibodies |
>84 publications with FLT3 and Inflammation |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>72 publications with FLT3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Lung Diseases Antibodies |
>46 publications with FLT3 and Lung Diseases |
Melanoma Antibodies |
>44 publications with FLT3 and Melanoma |
Organs/Tissues associated with FLT3 elisa kit
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