Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow FLT4 rightarrow Human FLT4  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Macrophages Antibody
 • Otoraplin Recombinant Protein
 • COASY Antibody
 • YWHAB - 14-3-3 Beta Antibody
 • ALP ELISA Kit
 • Glutathione Reductase (GSR) Assay Kit
 • BCL2-adenovirus E1B 19 kDa protein-interacting protein 3 (Bn... Recombinant Protein
 • Immunoglobulin G (IgG) ELISA Kit
 • BCL10 - BCL-10 Antibody
 • Leptin Triple Antagonist Recombinant Protein
 • FOS ELISA Kit
 • Aquaporin 4 (AQP-4) ELISA Kit
 • Gzms-B ELISA Kit
 • Cochlin (COCH) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

FLT4 elisa kit :: Human fms-related tyrosine kinase 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS703153 (SPECIAL PROMOTIONAL PRICING for a limited time)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

fms-related tyrosine kinase 4 (FLT4), ELISA Kit

★Popular Item★
 Also Known As   

Human Vascuar endothelial cell growth factor receptor 3, VEGFR-3/Flt-4 ELISA Kit

 Product Synonym Names    Human Vascuar endothelial cell growth factor receptor 3; VEGFR-3/Flt-4 ELISA Kit; FLT41; LMPH1A; PCL; VEGFR3; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; vascular endothelial growth factor receptor 3; fms-related tyrosine kinase 4
 Product Gene Name   

FLT4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS703153 Testing Data    Testing Data PDF
 OMIM    602089
 3D Structure    ModBase 3D Structure for P35916
Section Bar
 Species Reactivity    Human
Section Bar
 Specificity    This assay has high sensitivity and excellent specificity for detection of Human FLT4. No significant cross-reactivity or interference between Human FLT4 and analogues was observed.
Section Bar
 Samples    Serum, plasma, cell culture supernates, tissue homogenates
 Detection Range    0.312 ng/ml-20 ng/ml
 Sensitivity    0.078 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
Section Bar
 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FLT4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FLT4 purchase    MBS703153 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the fms-related tyrosine kinase 4 (FLT4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312 ng/ml-20 ng/ml in biological research samples containing FLT4, with an estimated sensitivity of 0.078 ng/ml. The ELISA analytical biochemical technique of the MBS703153 kit is based on FLT4 antibody-FLT4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLT4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLT4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernates, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
Section Bar
 Typical Testing Data/Standard Curve (for reference only) of FLT4 elisa kit    FLT4 elisa kit Typical Testing Data/Standard Curve (for reference only) image
Table BarTOPTable Bar
Sample Manual Insert of MBS703153. Click to request current manual
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for FLT4. It may not necessarily be applicable to this product.
 NCBI GI #    103472027
 NCBI GeneID    2324
 NCBI Accession #    NP_002011.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002020.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P35916 [Other Products]
 UniProt Secondary Accession #    Q16067; Q86W07; Q86W08; A8K6L4; B5A926 [Other Products]
 UniProt Related Accession #    P35916; AAB23636 [Other Products]
 Molecular Weight    152,757 Da
Table BarTOPTable Bar
 NCBI Official Full Name    vascular endothelial growth factor receptor 3 isoform 2
 NCBI Official Synonym Full Names    fms-related tyrosine kinase 4
 NCBI Official Symbol    FLT4 [Similar Products]
 NCBI Official Synonym Symbols   
PCL; FLT41; LMPH1A; VEGFR3
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 3; FLT-4; VEGFR-3; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; fms-like tyrosine kinase 4; tyrosine-protein kinase receptor FLT4
 UniProt Protein Name    Vascular endothelial growth factor receptor 3
 UniProt Synonym Protein Names   
Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
 Protein Family    Vascular endothelial growth factor receptor
 UniProt Gene Name    FLT4 [Similar Products]
 UniProt Synonym Gene Names    VEGFR3; VEGFR-3; FLT-4 [Similar Products]
 UniProt Entry Name    VGFR3_HUMAN
Section Bar
 NCBI Summary for FLT4    This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for FLT4    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.15 PublicationsManual assertion based on experiment in:Ref.4

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.2 PublicationsManual assertion based on experiment in:Ref.12

Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by MAZ51.3 PublicationsManual assertion based on experiment in:Ref.18
Table BarTOPTable Bar
 Research Articles on FLT4    1. The CXCL12-CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with FLT4 elisa kitPathways associated with FLT4 elisa kit
 Reference Product  PubMed Publications
 KDR elisa kit  >45 publications with FLT4 and KDR
 VEGFC elisa kit  >36 publications with FLT4 and VEGFC
 VEGFA elisa kit  >17 publications with FLT4 and VEGFA
 FIGF elisa kit  >6 publications with FLT4 and FIGF
 GRB2 elisa kit  >4 publications with FLT4 and GRB2
 PGF elisa kit  >3 publications with FLT4 and PGF
 VEGFB elisa kit  >3 publications with FLT4 and VEGFB
 SHC1 elisa kit  >1 publications with FLT4 and SHC1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with FLT4 elisa kitOrgans/Tissues associated with FLT4 elisa kit
 Disease Name  Pubmed Publications
 Lymphedema Antibodies  >29 publications with FLT4 and Lymphedema
 Lymphatic Diseases Antibodies  >28 publications with FLT4 and Lymphatic Diseases
 Carcinoma Antibodies  >18 publications with FLT4 and Carcinoma
 Edema Antibodies  >10 publications with FLT4 and Edema
 Adenocarcinoma Antibodies  >7 publications with FLT4 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >7 publications with FLT4 and Neoplasms, Experimental
 Leukemia, Myeloid, Acute Antibodies  >4 publications with FLT4 and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >4 publications with FLT4 and Inflammation
 Kidney Diseases Antibodies  >3 publications with FLT4 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with FLT4 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >94 publications with FLT4 and Vascular
 Embryonic Tissue Antibodies  >15 publications with FLT4 and Embryonic Tissue
 Lung Antibodies  >14 publications with FLT4 and Lung
 Placenta Antibodies  >11 publications with FLT4 and Placenta
 Muscle Antibodies  >10 publications with FLT4 and Muscle
 Heart Antibodies  >9 publications with FLT4 and Heart
 Bone Antibodies  >6 publications with FLT4 and Bone
 Lymph Node Antibodies  >5 publications with FLT4 and Lymph Node
 Brain Antibodies  >5 publications with FLT4 and Brain
 Intestine Antibodies  >4 publications with FLT4 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions