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GABBR2 elisa kit :: Human gamma-aminobutyric acid (GABA) B receptor, 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9319824 GABBR2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

gamma-aminobutyric acid (GABA) B receptor, 2 (GABBR2), ELISA Kit

★Popular Item★
 Also Known As   

Human Gamma-aminobutyric acid type B receptor subunit 2, GABBR2 ELISA Kit

 Product Synonym Names    Human Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) ELISA kit; FLJ36928; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099; G protein-coupled receptor 51; gamma-aminobutyric acid (GABA) B receptor; 2
 Product Gene Name   

GABBR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    607340
 3D Structure    ModBase 3D Structure for O75899
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    undiluted original Human body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    3.12 ng/ml - 100 ng/mL
 Sensitivity    1.0 ng/mL
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GABBR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GABBR2 purchase    MBS9319824 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gamma-aminobutyric acid (GABA) B receptor, 2 (GABBR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12 ng/ml - 100 ng/mL in biological research samples containing GABBR2, with an estimated sensitivity of 1.0 ng/mL. The ELISA analytical biochemical technique of the MBS9319824 kit is based on GABBR2 antibody-GABBR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GABBR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GABBR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GABBR2 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GABBR2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9319824. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GABBR2. It may not necessarily be applicable to this product.
 NCBI GI #    40255245
 NCBI GeneID    9568
 NCBI Accession #    NP_005449.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_005458.7 [Other Products]
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 UniProt Primary Accession #    O75899 [Other Products]
 UniProt Secondary Accession #    O75974; O75975; Q5VXZ2; Q8WX04; Q9P1R2; Q9UNR1; Q9UNS9 [Other Products]
 UniProt Related Accession #    O75899 [Other Products]
 Molecular Weight    105,821 Da
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 NCBI Official Full Name    gamma-aminobutyric acid type B receptor subunit 2
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) B receptor, 2
 NCBI Official Symbol    GABBR2 [Similar Products]
 NCBI Official Synonym Symbols   
HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099
[Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid type B receptor subunit 2; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coupled receptor 51; G-protein coupled receptor 51; gamma-aminobutyric acid B receptor 2
 UniProt Protein Name    Gamma-aminobutyric acid type B receptor subunit 2
 UniProt Synonym Protein Names   
G-protein coupled receptor 51; HG20
 Protein Family    Gamma-aminobutyric acid type B receptor
 UniProt Gene Name    GABBR2 [Similar Products]
 UniProt Synonym Gene Names    GPR51; GPRC3B; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2 [Similar Products]
 UniProt Entry Name    GABR2_HUMAN
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 NCBI Summary for GABBR2    The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
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 UniProt Comments for GABBR2    GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 3; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 9q22.1-q22.3

Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: protein binding; GABA-B receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway

Disease: Tobacco Addiction, Susceptibility To
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 Research Articles on GABBR2    1. The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GABBR2 elisa kitPathways associated with GABBR2 elisa kit
 Reference Product  PubMed Publications
 GABBR1 elisa kit  >7 publications with GABBR2 and GABBR1
 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with GABBR2 elisa kitOrgans/Tissues associated with GABBR2 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with GABBR2 and Nervous System Diseases
 Brain Diseases Antibodies  >8 publications with GABBR2 and Brain Diseases
 Seizures Antibodies  >5 publications with GABBR2 and Seizures
 Disease Models, Animal Antibodies  >5 publications with GABBR2 and Disease Models, Animal
 Movement Disorders Antibodies  >2 publications with GABBR2 and Movement Disorders
 Hypertension Antibodies  >2 publications with GABBR2 and Hypertension
 Autistic Disorder Antibodies  >2 publications with GABBR2 and Autistic Disorder
 Cognition Disorders Antibodies  >1 publications with GABBR2 and Cognition Disorders
 Chorea Antibodies  >1 publications with GABBR2 and Chorea
 Ataxia Antibodies  >1 publications with GABBR2 and Ataxia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >53 publications with GABBR2 and Brain
 Embryonic Tissue Antibodies  >3 publications with GABBR2 and Embryonic Tissue
 Kidney Antibodies  >3 publications with GABBR2 and Kidney
 Eye Antibodies  >2 publications with GABBR2 and Eye
 Lung Antibodies  >1 publications with GABBR2 and Lung
 Uncharacterized Tissue Antibodies  >1 publications with GABBR2 and Uncharacterized Tissue
 Muscle Antibodies  >1 publications with GABBR2 and Muscle
 Testis Antibodies  >1 publications with GABBR2 and Testis
 Connective Tissue Antibodies  >1 publications with GABBR2 and Connective Tissue
 Thyroid Antibodies  >1 publications with GABBR2 and Thyroid
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