NP_005305.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,199 Da
NCBI Official Full Name
gastrin-releasing peptide receptor
NCBI Official Synonym Full Names
gastrin-releasing peptide receptor
NCBI Official Synonym Symbols
NCBI Protein Information
gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor
UniProt Protein Name
Gastrin-releasing peptide receptor
UniProt Synonym Protein Names
GRP-preferring bombesin receptor
UniProt Synonym Gene Names
UniProt Entry Name
GRPR_HUMAN
NCBI Summary for GRPR
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GRPR
GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: bombesin receptor activity; peptide receptor activity, G-protein coupled
Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation
Research Articles on GRPR
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Products associated with GRPR elisa kit
Pathways associated with GRPR elisa kit
Diseases associated with GRPR elisa kit
Organs/Tissues associated with GRPR elisa kit
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