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GAN elisa kit :: Human gigaxonin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS940970
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

gigaxonin (GAN), ELISA Kit

 Also Known As   

Human Gigaxonin, GAN ELISA Kit

 Product Synonym Names    Human Gigaxonin (GAN) ELISA kit; FLJ38059; GAN1; KLHL16; kelch-like protein 16; gigaxonin
 Product Gene Name   

GAN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS940970 Testing Data    Testing Data PDF
 OMIM    605379
 3D Structure    ModBase 3D Structure for Q9H2C0
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human GAN. No significant cross-reactivity or interference between Human GAN and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    23.5 pg/ml-1500 pg/ml
 Sensitivity    5.86 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Ubiquitin
 Protein Biological Process 3    Ubl conjugation pathway
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GAN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GAN purchase    MBS940970 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gigaxonin (GAN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 23.5 pg/ml-1500 pg/ml in biological research samples containing GAN, with an estimated sensitivity of 5.86 pg/ml. The ELISA analytical biochemical technique of the MBS940970 kit is based on GAN antibody-GAN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GAN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GAN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for GAN elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for GAN has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any GAN present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GAN is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GAN bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of GAN elisa kit    GAN elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS940970. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GAN. It may not necessarily be applicable to this product.
 NCBI GI #    11545731
 NCBI GeneID    8139
 NCBI Accession #    NP_071324.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022041.3 [Other Products]
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 UniProt Primary Accession #    Q9H2C0 [Other Products]
 UniProt Related Accession #    Q9H2C0 [Other Products]
 Molecular Weight    67,638 Da
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 NCBI Official Full Name    gigaxonin
 NCBI Official Synonym Full Names    gigaxonin
 NCBI Official Symbol    GAN [Similar Products]
 NCBI Official Synonym Symbols   
GAN1; KLHL16
[Similar Products]
 NCBI Protein Information    gigaxonin; kelch-like protein 16; kelch-like family member 16
 UniProt Protein Name    Gigaxonin
 UniProt Synonym Protein Names   
Kelch-like protein 16
 Protein Family    Gigaxonin
 UniProt Gene Name    GAN [Similar Products]
 UniProt Synonym Gene Names    GAN1; KLHL16 [Similar Products]
 UniProt Entry Name    GAN_HUMAN
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 NCBI Summary for GAN    This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
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 UniProt Comments for GAN    GAN: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. Defects in GAN are the cause of giant axonal neuropathy (GAN). GAN is a severe autosomal recessive sensorimotor neuropathy affecting both the peripheral nerves and the central nervous system. It is characterized by neurofilament accumulation, leading to segmental distention of axons.

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein binding

Biological Process: protein ubiquitination

Disease: Giant Axonal Neuropathy 1, Autosomal Recessive
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 Research Articles on GAN    1. A novel missense mutation in four siblings born to consanguineous parents of Arab origin with clinical and molecular features compatible with giant axonal neuropathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GAN elisa kitPathways associated with GAN elisa kit
 Reference Product  PubMed Publications
 MAP1B elisa kit  >5 publications with GAN and MAP1B
 TBCB elisa kit  >2 publications with GAN and TBCB
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with GAN elisa kitOrgans/Tissues associated with GAN elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7359 publications with GAN and Neoplasms
 Liver Neoplasms Antibodies  >1216 publications with GAN and Liver Neoplasms
 Liver Diseases Antibodies  >1147 publications with GAN and Liver Diseases
 Lung Neoplasms Antibodies  >788 publications with GAN and Lung Neoplasms
 Nervous System Diseases Antibodies  >782 publications with GAN and Nervous System Diseases
 Liver Neoplasms, Experimental Antibodies  >688 publications with GAN and Liver Neoplasms, Experimental
 Drug Toxicity Antibodies  >582 publications with GAN and Drug Toxicity
 Central Nervous System Diseases Antibodies  >482 publications with GAN and Central Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >432 publications with GAN and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >256 publications with GAN and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1037 publications with GAN and Lung
 Brain Antibodies  >784 publications with GAN and Brain
 Kidney Antibodies  >457 publications with GAN and Kidney
 Muscle Antibodies  >385 publications with GAN and Muscle
 Intestine Antibodies  >286 publications with GAN and Intestine
 Eye Antibodies  >185 publications with GAN and Eye
 Prostate Antibodies  >137 publications with GAN and Prostate
 Embryonic Tissue Antibodies  >137 publications with GAN and Embryonic Tissue
 Thyroid Antibodies  >129 publications with GAN and Thyroid
 Uterus Antibodies  >125 publications with GAN and Uterus
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