NP_004237.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,001 Da
NCBI Official Full Name
glucagon-like peptide 2 receptor
NCBI Official Synonym Full Names
glucagon-like peptide 2 receptor
NCBI Protein Information
glucagon-like peptide 2 receptor; GLP-2R; GLP-2-R; GLP-2 receptor
UniProt Protein Name
Glucagon-like peptide 2 receptor
UniProt Synonym Gene Names
UniProt Entry Name
GLP2R_HUMAN
NCBI Summary for GLP2R
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq, Jul 2008]
UniProt Comments for GLP2R
GLP2R: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; glucagon receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of cell proliferation
Research Articles on GLP2R
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Products associated with GLP2R elisa kit
Pathways associated with GLP2R elisa kit
Organs/Tissues associated with GLP2R elisa kit
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