NP_004482.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
170,514 Da
NCBI Official Full Name
rho GTPase-activating protein 35
NCBI Official Synonym Full Names
Rho GTPase activating protein 35
NCBI Official Synonym Symbols
GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP [Similar Products]
NCBI Protein Information
rho GTPase-activating protein 35; rho GAP p190A; glucocorticoid receptor repression factor 1; glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1
UniProt Protein Name
Rho GTPase-activating protein 35
UniProt Synonym Protein Names
Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A
UniProt Synonym Gene Names
UniProt Entry Name
RHG35_HUMAN
NCBI Summary for GRLF1
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
UniProt Comments for GRLF1
GRF-1: the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTP-ase activating protein (GAP). May also act as a tumor suppressor. Two splice variant isoforms have been described.
Protein type: GAPs, Rac/Rho; Tumor suppressor; GAPs; Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: nucleus; cytosol; actin cytoskeleton
Molecular Function: DNA binding; GTP binding; transcription corepressor activity
Biological Process: regulation of cell shape; axon guidance; regulation of small GTPase mediated signal transduction; camera-type eye development; negative regulation of Rho protein signal transduction; transcription, DNA-dependent; small GTPase mediated signal transduction; neural tube closure; forebrain development; negative regulation of vascular permeability; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on GRLF1
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Pathways associated with GRLF1 elisa kit
Diseases associated with GRLF1 elisa kit
Organs/Tissues associated with GRLF1 elisa kit
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