NP_000818.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,506 Da
NCBI Official Full Name
glutamate receptor 1 isoform 1
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, AMPA 1
NCBI Official Synonym Symbols
GLUH1; GLUR1; GLURA; GluA1; HBGR1 [Similar Products]
NCBI Protein Information
glutamate receptor 1; AMPA 1; gluR-1; gluR-A; gluR-K1; AMPA-selective glutamate receptor 1
UniProt Protein Name
Glutamate receptor 1
UniProt Synonym Protein Names
AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1
UniProt Synonym Gene Names
UniProt Entry Name
GRIA1_HUMAN
NCBI Summary for GRIA1
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIA1
GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: postsynaptic membrane; synaptic vesicle; recycling endosome; endoplasmic reticulum membrane; cell surface; cell soma; postsynaptic density; dendrite; plasma membrane; dendritic spine; cell junction
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; glutamate receptor activity; PDZ domain binding
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; long-term memory; ionotropic glutamate receptor signaling pathway; receptor internalization; signal transduction
Research Articles on GRIA1
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