NP_001243239.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glutaminase kidney isoform, mitochondrial isoform 2
NCBI Official Synonym Full Names
glutaminase
NCBI Protein Information
glutaminase kidney isoform, mitochondrial; K-glutaminase; glutaminase C; L-glutamine amidohydrolase; glutaminase, phosphate-activated
UniProt Protein Name
Glutaminase kidney isoform, mitochondrial
UniProt Synonym Protein Names
K-glutaminase; L-glutamine amidohydrolase
UniProt Synonym Gene Names
UniProt Entry Name
GLSK_HUMAN
NCBI Summary for GLS
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Comments for GLS
glutaminase: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Belongs to the glutaminase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 3.5.1.2; Hydrolase; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Energy Metabolism - nitrogen; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline
Chromosomal Location of Human Ortholog: 2q32-q34
Cellular Component: mitochondrion; mitochondrial matrix; cytosol
Molecular Function: protein binding; glutaminase activity
Biological Process: synaptic transmission; glutamate secretion; suckling behavior; neurotransmitter secretion; glutamine catabolic process; neurological control of breathing; glutamate biosynthetic process; amino acid biosynthetic process; protein homotetramerization
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Pathways associated with GLS elisa kit
Diseases associated with GLS elisa kit
Organs/Tissues associated with GLS elisa kit
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