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GSR elisa kit :: Human glutathione reductase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS702351
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

glutathione reductase (GSR), ELISA Kit

 Also Known As   

Human Glutathione Reductase, GR ELISA Kit

 Product Synonym Names    Human Glutathione Reductase (GR) ELISA Kit; MGC78522; ; glutathione reductase
 Product Gene Name   

GSR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS702351 Testing Data    Testing Data PDF
 OMIM    138300
 3D Structure    ModBase 3D Structure for P00390
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human GR. No significant cross-reactivity or interference between human GR and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Sandwich
 Detection Range    0.625 mU/ml -40 mU/ml.
 Sensitivity    The minimum detectable dose of human GR is typically less than 0.156 mU/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GSR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GSR purchase    MBS702351 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the glutathione reductase (GSR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 mU/ml -40 mU/ml in biological research samples containing GSR, with an estimated sensitivity of The minimum detectable dose of human GR is typically less than 0.156 mU/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS702351 kit is based on GSR antibody-GSR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GSR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GSR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GSR elisa kit

   Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for GR has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any GR present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GR is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GR bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of GSR elisa kit    GSR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS702351. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GSR. It may not necessarily be applicable to this product.
 NCBI GI #    50301238
 NCBI GeneID    2936
 NCBI Accession #    NP_000628.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000637.3 [Other Products]
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 UniProt Primary Accession #    P00390 [Other Products]
 UniProt Secondary Accession #    Q7Z5C9; Q9NP63; C8KIL8; C8KIL9; C8KIM0; D3DSV3 [Other Products]
 UniProt Related Accession #    P00390 [Other Products]
 Molecular Weight    56,257 Da
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 NCBI Official Full Name    glutathione reductase, mitochondrial isoform 1
 NCBI Official Synonym Full Names    glutathione reductase
 NCBI Official Symbol    GSR [Similar Products]
 NCBI Official Synonym Symbols   
HEL-75
[Similar Products]
 NCBI Protein Information    glutathione reductase, mitochondrial; GR; GRase; epididymis luminal protein 75
 UniProt Protein Name    Glutathione reductase, mitochondrial
 Protein Family    Glutathione reductase
 UniProt Gene Name    GSR [Similar Products]
 UniProt Synonym Gene Names    GLUR; GRD1; GR; GRase [Similar Products]
 UniProt Entry Name    GSHR_HUMAN
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 NCBI Summary for GSR    This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
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 UniProt Comments for GSR    Function: Maintains high levels of reduced glutathione in the cytosol.

Catalytic activity: 2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor: Binds 1 FAD per subunit.
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 Research Articles on GSR    1. GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GSR elisa kitPathways associated with GSR elisa kit
 Reference Product  PubMed Publications
 GPX1 elisa kit  >22 publications with GSR and GPX1
 GSS elisa kit  >7 publications with GSR and GSS
 GPX4 elisa kit  >7 publications with GSR and GPX4
 GPX2 elisa kit  >4 publications with GSR and GPX2
 GPX3 elisa kit  >4 publications with GSR and GPX3
 GSTA1 elisa kit  >2 publications with GSR and GSTA1
 GSTA2 elisa kit  >1 publications with GSR and GSTA2
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Sulfation Biotransformation Reaction Pathway antibodies  Sulfation Biotransformation Reaction Pathway Diagram
Diseases associated with GSR elisa kitOrgans/Tissues associated with GSR elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >79 publications with GSR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >48 publications with GSR and Cardiovascular Diseases
 Liver Diseases Antibodies  >19 publications with GSR and Liver Diseases
 Inflammation Antibodies  >14 publications with GSR and Inflammation
 Hypertension Antibodies  >13 publications with GSR and Hypertension
 Necrosis Antibodies  >13 publications with GSR and Necrosis
 Heart Diseases Antibodies  >9 publications with GSR and Heart Diseases
 Drug-Induced Liver Injury Antibodies  >9 publications with GSR and Drug-Induced Liver Injury
 Drug-Related Side Effects and Adverse Reactions Antibodies  >8 publications with GSR and Drug-Related Side Effects and Adverse Reactions
 Poisoning Antibodies  >8 publications with GSR and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >5925 publications with GSR and Other
 Root Antibodies  >451 publications with GSR and Root
 Leaf Antibodies  >309 publications with GSR and Leaf
 Seed Antibodies  >160 publications with GSR and Seed
 Flower Antibodies  >67 publications with GSR and Flower
 Whole Plant Antibodies  >57 publications with GSR and Whole Plant
 Floral Meristem Antibodies  >2 publications with GSR and Floral Meristem
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