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GP1BB elisa kit :: Human glycoprotein Ib (platelet) , beta polypeptide ELISA Kit

Scan QR to view Datasheet Catalog #    MBS931449
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

glycoprotein Ib (platelet) , beta polypeptide (GP1BB), ELISA Kit

 Also Known As   

Human Platelet glycoprotein Ib beta chain, GP1BB ELISA Kit

 Product Synonym Names    Human Platelet glycoprotein Ib beta chain (GP1BB) ELISA kit; CD42c; glycoprotein Ib; beta polypeptide; nuclear localization signal deleted in velocardiofacial syndrome; glycoprotein Ib (platelet); beta polypeptide
 Product Gene Name   

GP1BB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS931449 Testing Data    Testing Data PDF
 OMIM    gene 231200
 3D Structure    ModBase 3D Structure for P13224
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human GP1BB. No significant cross-reactivity or interference between Human GP1BB and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Sandwich
 Detection Range    0.625 ng/ml-40 ng/ml
 Sensitivity    0.156 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Blood Coagulation
 Protein Biological Process 3    Blood coagulation
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GP1BB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GP1BB purchase    MBS931449 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the glycoprotein Ib (platelet), beta polypeptide (GP1BB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml-40 ng/ml in biological research samples containing GP1BB, with an estimated sensitivity of 0.156 ng/ml. The ELISA analytical biochemical technique of the MBS931449 kit is based on GP1BB antibody-GP1BB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GP1BB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GP1BB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GP1BB elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for GP1BB has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any GP1BB present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GP1BB is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GP1BB bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of GP1BB elisa kit    GP1BB elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS931449. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GP1BB. It may not necessarily be applicable to this product.
 NCBI GI #    4504073
 NCBI GeneID    2812
 NCBI Accession #    NP_000398.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000407.4 [Other Products]
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 UniProt Primary Accession #    P13224 [Other Products]
 UniProt Secondary Accession #    Q14422; Q8NG40 [Other Products]
 UniProt Related Accession #    P13224 [Other Products]
 Molecular Weight    21,718 Da
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 NCBI Official Full Name    platelet glycoprotein Ib beta chain
 NCBI Official Synonym Full Names    glycoprotein Ib (platelet), beta polypeptide
 NCBI Official Symbol    GP1BB [Similar Products]
 NCBI Official Synonym Symbols   
BS; CD42C; GPIBB; BDPLT1
[Similar Products]
 NCBI Protein Information    platelet glycoprotein Ib beta chain; GP-Ib beta; antigen CD42b-beta; nuclear localization signal deleted in velocardiofacial syndrome
 UniProt Protein Name    Platelet glycoprotein Ib beta chain
 UniProt Synonym Protein Names   
Antigen CD42b-beta; CD_antigen: CD42c
 Protein Family    Platelet glycoprotein
 UniProt Gene Name    GP1BB [Similar Products]
 UniProt Synonym Gene Names    GP-Ib beta; GPIb-beta; GPIbB [Similar Products]
 UniProt Entry Name    GP1BB_HUMAN
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 NCBI Summary for GP1BB    Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for GP1BB    GPIbB: Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium. Defects in GP1BB are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: platelet activation; cell surface receptor linked signal transduction; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway

Disease: Bernard-soulier Syndrome
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 Research Articles on GP1BB    1. genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA, GP1BB) and GP9 are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GP1BB elisa kitPathways associated with GP1BB elisa kit
 Reference Product  PubMed Publications
 GP1BA elisa kit  >4 publications with GP1BB and GP1BA
 GP9 elisa kit  >3 publications with GP1BB and GP9
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 GP1b-IX-V Activation Signalling Pathway antibodies  GP1b-IX-V Activation Signalling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with GP1BB elisa kitOrgans/Tissues associated with GP1BB elisa kit
 Disease Name  Pubmed Publications
 Bernard-Soulier Syndrome Antibodies  >4 publications with GP1BB and Bernard-Soulier Syndrome
 Thrombocytopenia Antibodies  >4 publications with GP1BB and Thrombocytopenia
 Cardiovascular Diseases Antibodies  >2 publications with GP1BB and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with GP1BB and Heart Diseases
 Chromosome Aberrations Antibodies  >1 publications with GP1BB and Chromosome Aberrations
 Immune System Diseases Antibodies  >1 publications with GP1BB and Immune System Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with GP1BB and Craniofacial Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with GP1BB and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with GP1BB and Blood
 Heart Antibodies  >1 publications with GP1BB and Heart
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