NP_001257710.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,315 Da
NCBI Official Full Name
granzyme H isoform 3
NCBI Official Synonym Full Names
granzyme H (cathepsin G-like 2, protein h-CCPX)
NCBI Official Synonym Symbols
CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2 [Similar Products]
NCBI Protein Information
granzyme H; cytotoxin serine protease-C; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte-associated serine esterase 1
UniProt Protein Name
Granzyme H
UniProt Synonym Protein Names
CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C
UniProt Synonym Gene Names
UniProt Entry Name
GRAH_HUMAN
NCBI Summary for GZMH
The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
UniProt Comments for GZMH
Function: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.2 PublicationsManual assertion based on experiment in:Ref.8
Enzyme regulation: Inhibited by SERPINB1.1 PublicationManual assertion based on experiment in:Ref.9
Research Articles on GZMH
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Products associated with GZMH elisa kit
Pathways associated with GZMH elisa kit
Diseases associated with GZMH elisa kit
Organs/Tissues associated with GZMH elisa kit
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