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GHBP elisa kit :: Human growth hormone-binding protein (GHBP) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS266601
Typical Standard Curve/Testing Data
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $405 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

growth hormone-binding protein (GHBP), ELISA Kit

★Popular Item★
 Also Known As   

Human growth hormone-binding protein (GHBP) ELISA Kit

 Product Gene Name   

GHBP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS266601 COA    COA PDF
 OMIM    gene 604271
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 Species Reactivity    Human
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 Specificity    No cross-reaction with other factors.
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 Samples    Serum, plasma or cell culture supernatant
 Assay Type    Quantitative Sandwich
 Detection Range    200 ng/ml-3.12 ng/ml
 Sensitivity    Up to 0.6 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GHBP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GHBP purchase    MBS266601 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the growth hormone-binding protein (GHBP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 200 ng/ml-3.12 ng/ml in biological research samples containing GHBP, with an estimated sensitivity of Up to 0.6 ng/ml. The ELISA analytical biochemical technique of the MBS266601 kit is based on GHBP antibody-GHBP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GHBP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GHBP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma or cell culture supernatant. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GHBP elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human GHBP monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Standard Curve/Testing Data of GHBP elisa kit    GHBP elisa kit Typical Standard Curve/Testing Data image
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Sample Manual Insert of MBS266601. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GHBP. It may not necessarily be applicable to this product.
 NCBI GI #    4503993
 NCBI GeneID    2690
 NCBI Accession #    NP_000154.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000163.4 [Other Products]
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 UniProt Secondary Accession #    Q9HCX2 [Other Products]
 UniProt Related Accession #    P10912 [Other Products]
 Molecular Weight    69,237 Da
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 NCBI Official Full Name    growth hormone receptor isoform 1
 NCBI Official Synonym Full Names    growth hormone receptor
 NCBI Official Symbol    GHR [Similar Products]
 NCBI Official Synonym Symbols   
GHBP
[Similar Products]
 NCBI Protein Information    growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
 UniProt Protein Name    Growth hormone receptor
 UniProt Synonym Protein Names   
Somatotropin receptorCleaved into the following chain:Growth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein
 UniProt Gene Name    GHR [Similar Products]
 UniProt Synonym Gene Names    GH receptor; GH-binding protein; GHBP [Similar Products]
 UniProt Entry Name    GHR_HUMAN
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 NCBI Summary for GHBP    This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
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 UniProt Comments for GHBP    GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; extracellular region; integral to membrane; receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; growth factor binding; peptide hormone binding; protein kinase binding

Biological Process: succinate metabolic process; oxaloacetate metabolic process; activation of MAPK activity; positive regulation of multicellular organism growth; fatty acid metabolic process; tyrosine phosphorylation of JAK2 protein; response to estradiol stimulus; positive regulation of tyrosine phosphorylation of Stat3 protein; 2-oxoglutarate metabolic process; allantoin metabolic process; receptor internalization; creatinine metabolic process; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; citrate metabolic process; valine metabolic process; regulation of multicellular organism growth; endocytosis; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; insulin-like growth factor receptor signaling pathway; response to cycloheximide; taurine metabolic process

Disease: Hypercholesterolemia, Familial; Laron Syndrome
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 Research Articles on GHBP    1. This study suggests for the first time that exon 3 deletion of GHR may predispose patients with active and controlled acromegaly to a higher risk of vertebral fractures.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GHBP elisa kitPathways associated with GHBP elisa kit
 Reference Product  PubMed Publications
 JAK2 elisa kit  >172 publications with GHBP and JAK2
 STAT5B elisa kit  >60 publications with GHBP and STAT5B
 PRL elisa kit  >52 publications with GHBP and PRL
 STAT3 elisa kit  >29 publications with GHBP and STAT3
 GH1 elisa kit  >21 publications with GHBP and GH1
 SOCS3 elisa kit  >20 publications with GHBP and SOCS3
 IRS1 elisa kit  >15 publications with GHBP and IRS1
 SOCS2 elisa kit  >14 publications with GHBP and SOCS2
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with GHBP elisa kitOrgans/Tissues associated with GHBP elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >84 publications with GHBP and Nervous System Diseases
 Laron Syndrome Antibodies  >81 publications with GHBP and Laron Syndrome
 Disease Models, Animal Antibodies  >63 publications with GHBP and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >50 publications with GHBP and Cardiovascular Diseases
 Weight Gain Antibodies  >50 publications with GHBP and Weight Gain
 Carcinoma Antibodies  >48 publications with GHBP and Carcinoma
 Liver Diseases Antibodies  >48 publications with GHBP and Liver Diseases
 Necrosis Antibodies  >35 publications with GHBP and Necrosis
 Kidney Diseases Antibodies  >34 publications with GHBP and Kidney Diseases
 Inflammation Antibodies  >27 publications with GHBP and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >408 publications with GHBP and Liver
 Muscle Antibodies  >151 publications with GHBP and Muscle
 Brain Antibodies  >127 publications with GHBP and Brain
 Bone Antibodies  >93 publications with GHBP and Bone
 Kidney Antibodies  >92 publications with GHBP and Kidney
 Adipose Tissue Antibodies  >64 publications with GHBP and Adipose Tissue
 Ovary Antibodies  >58 publications with GHBP and Ovary
 Connective Tissue Antibodies  >55 publications with GHBP and Connective Tissue
 Heart Antibodies  >49 publications with GHBP and Heart
 Embryonic Tissue Antibodies  >47 publications with GHBP and Embryonic Tissue
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