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GMPS elisa kit :: Human guanine monphosphate synthetase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS940289
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

guanine monphosphate synthetase (GMPS), ELISA Kit

★Popular Item★
 Also Known As   

Human GMP synthase [glutamine-hydrolyzing], GMPS ELISA Kit

 Product Synonym Names    Human GMP synthase [glutamine-hydrolyzing] (GMPS) ELISA kit; GMP synthase; GMP synthetase; MLL/GMPS fusion protein; glutamine amidotransferase; guanine monophosphate synthetase; guanosine 5 -monophosphate synthase; guanine monphosphate synthetase
 Product Gene Name   

GMPS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS940289 Testing Data    Testing Data PDF
 OMIM    600358
 3D Structure    ModBase 3D Structure for P49915
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human GMPS. No significant cross-reactivity or interference between Human GMPS and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    31.25 pg/ml-2000 pg/ml
 Sensitivity    7.81 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Biosynthesis/Metabolism
 Protein Biological Process 2    Adenosine synthesis and metabolism
 Protein Biological Process 3    GMP biosynthesis
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GMPS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GMPS purchase    MBS940289 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the guanine monphosphate synthetase (GMPS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.25 pg/ml-2000 pg/ml in biological research samples containing GMPS, with an estimated sensitivity of 7.81 pg/ml. The ELISA analytical biochemical technique of the MBS940289 kit is based on GMPS antibody-GMPS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GMPS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GMPS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for GMPS elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for GMPS has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any GMPS present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GMPS is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GMPS bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of GMPS elisa kit    GMPS elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS940289. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GMPS. It may not necessarily be applicable to this product.
 NCBI GI #    4504035
 NCBI GeneID    8833
 NCBI Accession #    NP_003866.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003875.2 [Other Products]
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 UniProt Primary Accession #    P49915 [Other Products]
 UniProt Secondary Accession #    A8K639; B4DXV7; F8W720 [Other Products]
 UniProt Related Accession #    P49915 [Other Products]
 Molecular Weight    76,715 Da
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 NCBI Official Full Name    GMP synthase
 NCBI Official Synonym Full Names    guanine monphosphate synthase
 NCBI Official Symbol    GMPS [Similar Products]
 NCBI Protein Information    GMP synthase [glutamine-hydrolyzing]; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; MLL/GMPS fusion protein; glutamine amidotransferase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase
 UniProt Protein Name    GMP synthase [glutamine-hydrolyzing]
 UniProt Synonym Protein Names   
GMP synthetase; Glutamine amidotransferase
 UniProt Gene Name    GMPS [Similar Products]
 UniProt Entry Name    GUAA_HUMAN
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 NCBI Summary for GMPS    In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GMPS    GMPS: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL.

Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Oncoprotein; Nucleotide Metabolism - purine; EC 6.3.5.2; Ligase

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: cytoplasm; cytosol

Molecular Function: pyrophosphatase activity; enzyme binding; GMP synthase activity; GMP synthase (glutamine-hydrolyzing) activity; ATP binding

Biological Process: response to drug; purine ribonucleoside monophosphate biosynthetic process; purine base biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; GMP biosynthetic process; glutamine metabolic process; purine base metabolic process

Disease: Leukemia, Acute Myeloid
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 Research Articles on GMPS    1. Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GMPS elisa kitDiseases associated with GMPS elisa kit
 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Ribonucleoside Monophosphate Biosynthesis Pathway antibodies  Purine Ribonucleoside Monophosphate Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with GMPS and Neoplasms
 Cardiovascular Diseases Antibodies  >22 publications with GMPS and Cardiovascular Diseases
 Leukemia, Myeloid, Acute Antibodies  >11 publications with GMPS and Leukemia, Myeloid, Acute
 Myocardial Ischemia Antibodies  >6 publications with GMPS and Myocardial Ischemia
 Cell Transformation, Neoplastic Antibodies  >4 publications with GMPS and Cell Transformation, Neoplastic
 Inflammation Antibodies  >4 publications with GMPS and Inflammation
 Chronic Disease Antibodies  >4 publications with GMPS and Chronic Disease
 Atherosclerosis Antibodies  >3 publications with GMPS and Atherosclerosis
 Drug Toxicity Antibodies  >3 publications with GMPS and Drug Toxicity
 Anemia Antibodies  >3 publications with GMPS and Anemia
Organs/Tissues associated with GMPS elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >60 publications with GMPS and Blood
 Bone Marrow Antibodies  >24 publications with GMPS and Bone Marrow
 Heart Antibodies  >16 publications with GMPS and Heart
 Vascular Antibodies  >15 publications with GMPS and Vascular
 Muscle Antibodies  >13 publications with GMPS and Muscle
 Mouth Antibodies  >8 publications with GMPS and Mouth
 Liver Antibodies  >7 publications with GMPS and Liver
 Spleen Antibodies  >7 publications with GMPS and Spleen
 Brain Antibodies  >5 publications with GMPS and Brain
 Lung Antibodies  >3 publications with GMPS and Lung
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