NP_001136065.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,621 Da
NCBI Official Full Name
inositol-tetrakisphosphate 1-kinase isoform a
NCBI Official Synonym Full Names
inositol-tetrakisphosphate 1-kinase
NCBI Official Synonym Symbols
NCBI Protein Information
inositol-tetrakisphosphate 1-kinase; ins(1,3,4)P(3) 5/6-kinase; inositol-triphosphate 5/6-kinase; inositol 1,3,4-triphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6-kinase
UniProt Protein Name
Inositol-tetrakisphosphate 1-kinase
UniProt Synonym Protein Names
Inositol 1,3,4-trisphosphate 5/6-kinase (EC:2.7.1.159); Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase
UniProt Synonym Gene Names
UniProt Entry Name
ITPK1_HUMAN
UniProt Comments for ITPK1
ITPK1: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Belongs to the ITPK1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.134; EC 2.7.1.159; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q31
Cellular Component: cytosol
Molecular Function: inositol tetrakisphosphate 1-kinase activity; magnesium ion binding; isomerase activity; catalytic activity; ATP binding
Biological Process: inositol phosphate metabolic process; dephosphorylation; signal transduction; blood coagulation; phosphorylation; inositol trisphosphate metabolic process
Research Articles on ITPK1
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Pathways associated with ITPK1 elisa kit
Products by Pathway |
Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3) Pathway Diagram |
D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram |
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies |
Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram |
Hemostasis Pathway antibodies |
Hemostasis Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Diseases associated with ITPK1 elisa kit
Organs/Tissues associated with ITPK1 elisa kit
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